VEGFD and ITGA9

Number of citations: 49 (PubMedID 15590642)
Data Source: HPRD (in vitro, in vivo)

		VEGFD	ITGA9
Name		vascular endothelial growth factor D	integrin subunit alpha 9
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Plasma Membrane Integrin Complex Basal Plasma Membrane Cell Surface Membrane Integrin Alpha9-beta1 Complex
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding Vascular Endothelial Growth Factor Receptor 3 Binding Receptor Ligand Activity	Protein Binding Signaling Receptor Activity Metal Ion Binding Integrin Binding Involved In Cell-matrix Adhesion
	Biological Process	Angiogenesis Response To Hypoxia Sprouting Angiogenesis Positive Regulation Of Cell Population Proliferation Response To Bacterium Cell Differentiation Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Fibroblast Proliferation Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Mast Cell Chemotaxis Dopaminergic Neuron Differentiation	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Neutrophil Chemotaxis Negative Regulation Of Vasoconstriction Cell-cell Adhesion
Pathways		Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization	Integrin cell surface interactions Integrin cell surface interactions ECM proteoglycans Signal transduction by L1
Diseases		Gastric cancer	Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		No GWAS studies recorded	Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Anti-human herpes virus 6 IE1A IgG seropositivity ( 33204752 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Heel bone mineral density ( 30598549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Mortality in sepsis ( 27639821 ) Nasopharyngeal carcinoma ( 19478819 ) Phospholipid levels (plasma) ( 22359512 ) Platelet count ( 32888494 ) PR interval ( 23139255 ) Pulse pressure ( 30224653 30578418 ) Response to antidepressants (symptom improvement) ( 29160301 ) Systolic blood pressure ( 30578418 )
Novel Interactors		None recorded	1 novel interactors: GPX1
Interacting Genes		4 interacting genes: FLT4 ITGA9 KDR VAMP3	6 interacting genes: ITGB1 NGF PXN SAT1 SPP1 VEGFD
Entrez ID		2277	3680
HPRD ID		02102	04910
Ensembl ID		ENSG00000165197	ENSG00000144668
Uniprot IDs		O43915	Q13797 Q8N6H6
PDB IDs		2XV7	Not available
GO Terms Enriched among Interactors		Vascular Endothelial Growth Factor Receptor Activity Lymph Vessel Development Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Growth Factor Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Lung Alveolus Development Vasculature Development Positive Regulation Of Endothelial Cell Proliferation Cell Surface Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Protein Autophosphorylation Positive Regulation Of Endothelial Cell Migration Protein Tyrosine Kinase Activity Regulation Of Endothelial Cell Proliferation Integrin Alpha9-beta1 Complex Cell-substrate Adhesion Cell Migration Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Proliferation Receptor Complex Positive Regulation Of ERK1 And ERK2 Cascade Cell Motility Response To Hydrogen Sulfide Cellular Response To Hydrogen Sulfide Post-embryonic Camera-type Eye Morphogenesis Vascular Endothelial Growth Factor Binding Positive Regulation Of Protein Phosphorylation Integrin Binding Involved In Cell-matrix Adhesion Positive Regulation Of Nitric Oxide Mediated Signal Transduction Endocardium Development Positive Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of CGMP-mediated Signaling Blood Vessel Endothelial Cell Differentiation Sorting Endosome Post-embryonic Eye Morphogenesis Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Regulation Of Histamine Secretion By Mast Cell Tube Morphogenesis Angiogenesis Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Early Endosome Vascular Wound Healing Positive Regulation Of Mitochondrial Depolarization	Angiogenesis Endothelial Cell Migration Regulation Of Collateral Sprouting Enzyme-linked Receptor Protein Signaling Pathway Myoblast Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Blood Vessel Endothelial Cell Migration Regulation Of Cell Population Proliferation Anatomical Structure Formation Involved In Morphogenesis Fibroblast Proliferation Protein Tyrosine Kinase Binding Axon Extension Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vascular Endothelial Growth Factor Receptor 3 Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Growth Muscle Cell Differentiation Striated Muscle Cell Differentiation Response To Vitamin Myoblast Fate Specification Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Neuron Projection Extension Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Transforming Growth Factor Beta Receptor Signaling Pathway Integrin Alpha7-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Regulation Of Neurogenesis Regulation Of Nervous System Development Integrin Alpha9-beta1 Complex Spermidine Acetylation Putrescine Catabolic Process Spermidine Binding Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion Neuron Apoptotic Process Regulation Of Cellular Component Organization Developmental Cell Growth Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Positive Regulation Of Neuron Maturation Diamine N-acetyltransferase Activity Regulation Of Estradiol Secretion Growth Factor Activity