GSE1 and EXOSC6

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		GSE1	EXOSC6
Gene Name		Gse1 coiled-coil protein	exosome component 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Exosome (RNase Complex) Nucleolus Cytosol
	Molecular Function	Protein Binding	Exoribonuclease Activity Poly(A) RNA Binding
	Biological Process		Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: C1orf94 C6orf165 CDC5L CEP63 DGCR6 EXOSC6 GOLGA2 NUDT18 RALBP1 RBM48 RBPMS RCOR3 RUNX1T1 TEKT4 TNIK TRIP6 XRCC6	35 interactors: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPP6 MRPL4 MRPS18B NDUFA13 NUDT21 PSMB1 RAB3GAP2 SKIV2L2 SRSF3 TUFM UPF2 XRN1 ZFP36
Entrez ID		23199	118460
HPRD ID		11066	12107
Ensembl ID		ENSG00000131149	ENSG00000223496
Uniprot IDs		Q14687	Q5RKV6
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		GDP Catabolic Process DGDP Catabolic Process DADP Catabolic Process RNA Metabolic Process Transcription, DNA-templated Signal Transduction In Response To DNA Damage Positive Regulation Of Protein Import Into Nucleus RNA Biosynthetic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Hyperosmotic Salinity Response Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Release Of Cytoplasmic Sequestered NF-kappaB Intracellular Signal Transduction Cellular Nitrogen Compound Metabolic Process Cellular Response To X-ray Purine Ribonucleoside Diphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process DNA Damage Checkpoint Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Ribonucleoside Diphosphate Catabolic Process Establishment Of Integrated Proviral Latency DNA Deamination Nucleoside Diphosphate Catabolic Process Cellular Hyperosmotic Response Hyperosmotic Salinity Response Activation Of JNKK Activity Establishment Of Viral Latency Regulation Of Protein Localization To Nucleus Nitrogen Compound Metabolic Process Deoxyribonucleoside Diphosphate Metabolic Process Regulation Of Nucleocytoplasmic Transport Cellular Response To Salt Stress Centriole Replication Purine Ribonucleoside Catabolic Process Cell Cycle Checkpoint DNA Recombination Positive Regulation Of Intracellular Transport Positive Regulation Of SMAD Protein Import Into Nucleus DNA Ligation Microvillus Assembly Cellular Response To Stress Regulation Of Binding Microvillus Organization Regulation Of Intracellular Protein Transport Regulation Of SMAD Protein Import Into Nucleus	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process RRNA Metabolic Process Aromatic Compound Catabolic Process Ribosome Biogenesis RRNA Processing Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA RNA Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Processing Cellular Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Histone MRNA Metabolic Process MRNA Processing RNA Splicing Metabolic Process RNA 3'-end Processing RNA Splicing, Via Transesterification Reactions RNA Localization DNA Deamination Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Intracellular MRNA Localization Mitochondrial Translational Elongation MRNA 3'-end Processing Mitochondrion Organization Mitochondrial Translation MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
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