MLANA and NEDD4

Number of citations of the paper that reports this interaction (PMID 15703212)
17

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MLANA	NEDD4
Gene Name		melan-A	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Integral Component Of Plasma Membrane Melanosome	Ubiquitin Ligase Complex Chromatin Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Apicolateral Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding Ligase Activity Sodium Channel Inhibitor Activity Protein Domain Specific Binding Beta-2 Adrenergic Receptor Binding Ubiquitin Binding Phosphoserine Binding Phosphothreonine Binding Ubiquitin Protein Ligase Activity RNA Polymerase Binding Proline-rich Region Binding
	Biological Process		Adaptive Immune Response Outflow Tract Morphogenesis Endocardial Cushion Development Protein Monoubiquitination Protein Targeting To Lysosome Lysosomal Transport Neuromuscular Junction Development Negative Regulation Of Sodium Ion Transport Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Ubiquitination Transmission Of Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Development Receptor Internalization Receptor Catabolic Process Cellular Response To UV Regulation Of Ion Transmembrane Transport T Cell Activation Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Glucocorticoid Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Development Involved In Symbiotic Interaction Positive Regulation Of Protein Catabolic Process Positive Regulation Of Nucleocytoplasmic Transport Blood Vessel Morphogenesis Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Progesterone Receptor Signaling Pathway Response To Calcium Ion Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways			Downregulation of ERBB4 signaling Antigen processing: Ubiquitination & Proteasome degradation ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Adaptive Immune System
Drugs
Diseases
GWAS		Multiple sclerosis ( 22190364)	Brain connectivity ( 23471985) Chronic lymphocytic leukemia ( 20062064) Keloid ( 20711176)
Protein-Protein Interactions		2 interactors: ITCH NEDD4	215 interactors: ABL1 ABL2 ADRB2 AKT3 AMOT AMOTL1 AMPD2 ANKRD13D ANXA13 AP1G2 ARID1A ARRDC1 ARRDC3 ASPSCR1 AURKC BAIAP2 BECN1 BMPR1A BRCA2 C11orf63 CAD CALCOCO1 CAMK1D CAMK4 CAMKK2 CASP1 CASP3 CASP6 CASP7 CBLB CCNH CDC25C CDK5 CDK5R1 CLIC2 CLK3 CPSF1 CPSF6 CUEDC1 DAZAP2 DCUN1D1 DDX3X DDX54 DHX30 DIAPH1 DVL1 DYRK4 EBAG9 EGFR EPHA5 EPRS EPS15 ERBB3 ERBB4 ERMN FES FGF12 FGF21 FGFR1 FGFR2 FKBP3 FLT1 FLT4 FYN GBA GRB10 GRIN2A GRK4 GRK7 HGS HMCES HNRNPK HNRNPL HNRNPU HNRNPUL1 IGF1R IRS1 JUN KCNAB1 KCNAB2 KIAA1598 KIFC3 LAPTM5 LATS1 LITAF LUC7L2 MAP3K2 MAP3K3 MAP3K5 MAP4K5 MAPKAPK3 MARK2 MARK4 MLANA MOB3A MRPL19 MTMR4 MYCN N4BP2 N4BP3 NDFIP1 NDFIP2 NFE2 NHP2 NSRP1 NTRK1 NUDT21 PARP16 PDGFRB PKN2 PLK1 PLK2 PMEPA1 POLR2A POLR2B POLR2C POLR2E POLR2M POLR3A PRKG2 PRKX PRPF8 PRR16 PRRG1 PRRG2 PSMD4 PTEN RAC1 RAD51AP1 RAF1 RANBP10 RAP2A RAPGEF2 RAPGEF6 RASGEF1A RASL11B RBCK1 RFT1 RNF11 RNF7 RPAP2 RPAP3 RPL18A RPS3A RPS6KA3 RPS6KA4 RPS6KB1 RUVBL1 SAAL1 SAMSN1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEPT9 SFTPC SGK1 SGK2 SH3KBP1 SIVA1 SLC23A2 SLC6A3 SMAD1 SMAD3 SMAD5 SMARCC1 SMO SNCA SP140L SPANXN3 SPRY2 SRC SRMS SRSF7 STK24 STK25 STK26 STK31 STK4 SULF1 SYK SYT1 TAF1B TBC1D7 TBK1 TCEANC TCP11L1 TEAD2 THRAP3 TNIK TOM1 TOM1L2 TP73 TRIM44 TRIM52 TRPV6 TSTA3 TTYH2 UBAP2L UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 UBE2M UBOX5 URI1 WBP1 WBP2 WEE1 WIBG YES1 YOD1
Entrez ID		2315	4734
HPRD ID		09269	03786
Ensembl ID			ENSG00000069869
Uniprot IDs		Q16655	P46934
PDB IDs		2GT9 2GTW 2GTZ 2GUO 3L6F 3MRO 3MRP 3MRQ 4EUP 4EUQ	2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8
Enriched GO Terms of Interacting Partners?		Protein K63-linked Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Interaction With Host Protein Polyubiquitination Intracellular Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Protein K29-linked Ubiquitination Regulation Of Protein Deubiquitination Positive Regulation Of T Cell Anergy Progesterone Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Glucocorticoid Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Protein Catabolic Process Negative Regulation Of Alpha-beta T Cell Proliferation Regulation Of T Cell Anergy Protein Targeting To Lysosome Positive Regulation Of T Cell Tolerance Induction Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Lysosome Cellular Macromolecule Catabolic Process Receptor Catabolic Process Protein Targeting To Vacuole Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Alpha-beta T Cell Activation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Defense Response To Virus Establishment Of Protein Localization To Vacuole Negative Regulation Of Signal Transduction Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Signaling Negative Regulation Of JNK Cascade Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Locomotion Negative Regulation Of Stress-activated MAPK Cascade Immune Response Protein K48-linked Ubiquitination Endocardial Cushion Development	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Phosphorylation Response To Growth Factor Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Cell Communication Cellular Protein Modification Process Regulation Of Phosphorylation Signal Transduction Regulation Of Protein Phosphorylation Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Phosphorylation Phosphate-containing Compound Metabolic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cell Death Regulation Of Metabolic Process Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Catalytic Activity Regulation Of Cellular Component Organization Regulation Of Cellular Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Cellular Metabolic Process Positive Regulation Of Kinase Activity Peptidyl-amino Acid Modification
Tagcloud ?		acral ajcc amenable annotated antiphosphohistone anywhere breslow dermal designation figure figures histopathologic immunodetection lentiginous lentigo maligna mart melan melanocytic mitoses mitotic nodular pearson phh3 phosphohistone refinement tnm ulceration unclassified	accepted colocalization colocalized conjugating cooperation cysteine cytoplasm deleted e2 e6ap enabled hect ligase neural neurites perinuclear periphery simultaneous specificities transfer ubc4 ubch5b ubch5c ubch6 ubch7 ubiquitin ubiquitination ubiquitins ww
Tagcloud (Difference) ?		acral ajcc amenable annotated antiphosphohistone anywhere breslow dermal designation figure figures histopathologic immunodetection lentiginous lentigo maligna mart melan melanocytic mitoses mitotic nodular pearson phh3 phosphohistone refinement tnm ulceration unclassified	accepted colocalization colocalized conjugating cooperation cysteine cytoplasm deleted e2 e6ap enabled hect ligase neural neurites perinuclear periphery simultaneous specificities transfer ubc4 ubch5b ubch5c ubch6 ubch7 ubiquitin ubiquitination ubiquitins ww
Tagcloud (Intersection) ?