CUL9 and PLXNB3

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		CUL9	PLXNB3
Gene Name		cullin 9	plexin B3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cullin-RING Ubiquitin Ligase Complex	Intracellular Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding ATP Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding Rho GDP-dissociation Inhibitor Binding
	Biological Process	Microtubule Cytoskeleton Organization Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Nuclear Division Protein Ubiquitination	Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell Adhesion Axon Guidance Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Cell Migration Negative Regulation Of GTPase Activity Positive Chemotaxis Cell Chemotaxis Semaphorin-plexin Signaling Pathway
Pathways			Axon guidance Semaphorin interactions Other semaphorin interactions
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: PLXNB3 TP53 UBC UBE2E2 UBE2G2 UBE2L3	8 interactors: ARHGEF11 BTBD3 CUL7 CUL9 MAGI2 MAGI3 RIT2 SPOCK2
Entrez ID		23113	5365
HPRD ID		06317	02198
Ensembl ID		ENSG00000112659	ENSG00000198753
Uniprot IDs		Q8IWT3	A8K920 B7Z3H9 Q9ULL4
PDB IDs		2JUF
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Protein K48-linked Ubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Cycle Arrest Cellular Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Cellular Response To Decreased Oxygen Levels Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Notch Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint	Neurotrophin Signaling Pathway Nervous System Development Cytokinesis Planar Cell Polarity Pathway Involved In Axis Elongation Regulation Of Mitotic Nuclear Division Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Catalytic Activity Generation Of Neurons Neurogenesis Cell Morphogenesis Involved In Differentiation Cell Development Cellular Response To Organic Substance Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Neuron Projection Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Regulation Of Cell Division Negative Regulation Of Activin Receptor Signaling Pathway Signaling Glomerular Visceral Epithelial Cell Development Cell Communication Positive Regulation Of Cell Projection Organization Positive Regulation Of Hydrolase Activity Cell Cycle Process Cell Morphogenesis Positive Regulation Of Phosphoprotein Phosphatase Activity Nerve Growth Factor Signaling Pathway Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Cytoskeleton Organization Regulation Of Catalytic Activity Positive Regulation Of Neuron Differentiation Anatomical Structure Morphogenesis Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Differentiation System Development Response To Organic Substance Positive Regulation Of Receptor Internalization Positive Regulation Of Cellular Metabolic Process Regulation Of Neuron Projection Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Cellular Response To Stimulus Regulation Of Activin Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Positive Regulation Of Neurogenesis Cell Cycle Cell Division Microtubule Cytoskeleton Organization
Tagcloud ?		abundance apaf cardiomyocytes conversely cyt cytochrome cytosolic damaged degradation e3 engaged glioma knocked ligase likewise mitochondrial mitochondrially myotubes neuroblastoma neurons parc parkin postmitotic proliferating proteasome released survive ubiquitination withstand	alias amplifications bgn casp9 ccnc cgh e2f5 eck efnb3 epha2 ercc1 fgf3 fgr frap1 hspg2 il12a l1cam lamc1 mexican nonaffected outline pctk2 pctk3 plexr tnfrsf10a tnfrsf10b tp73 turned underexpressed
Tagcloud (Difference) ?		abundance apaf cardiomyocytes conversely cyt cytochrome cytosolic damaged degradation e3 engaged glioma knocked ligase likewise mitochondrial mitochondrially myotubes neuroblastoma neurons parc parkin postmitotic proliferating proteasome released survive ubiquitination withstand	alias amplifications bgn casp9 ccnc cgh e2f5 eck efnb3 epha2 ercc1 fgf3 fgr frap1 hspg2 il12a l1cam lamc1 mexican nonaffected outline pctk2 pctk3 plexr tnfrsf10a tnfrsf10b tp73 turned underexpressed
Tagcloud (Intersection) ?