CUL9 and UBE2E2

Number of citations of the paper that reports this interaction (PMID 10521492)
30

Data Source:
HPRD (in vivo)

		CUL9	UBE2E2
Gene Name		cullin 9	ubiquitin-conjugating enzyme E2E 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cullin-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding ATP Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Microtubule Cytoskeleton Organization Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Nuclear Division Protein Ubiquitination	Cellular Response To DNA Damage Stimulus ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: PLXNB3 TP53 UBC UBE2E2 UBE2G2 UBE2L3	61 interactors: APP ARIH1 ARIH2 ARRDC3 BARD1 BRCA1 CHFR CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B FHL1 IPO11 ISG15 MARCH3 MDM2 MID1 MID2 MKRN3 MUL1 NFE2L2 PCGF2 PRAM1 RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF125 RNF14 RNF166 RNF185 RNF19A RNF2 RNF25 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBOX5 XIAP ZNRF1
Entrez ID		23113	7325
HPRD ID		06317	06779
Ensembl ID		ENSG00000112659
Uniprot IDs		Q8IWT3	Q96LR5
PDB IDs		2JUF	1Y6L
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Protein K48-linked Ubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Cycle Arrest Cellular Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Cellular Response To Decreased Oxygen Levels Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Notch Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Negative Regulation Of Viral Process Protein Autoubiquitination Catabolic Process Regulation Of Viral Process Proteolysis Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Viral Release From Host Cell Metabolic Process Histone Ubiquitination Negative Regulation Of Cellular Metabolic Process Histone H2A Ubiquitination Innate Immune Response Negative Regulation Of Viral Release From Host Cell Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Proteasomal Protein Catabolic Process Negative Regulation Of Viral Transcription Response To Stress Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response Regulation Of Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Cellular Response To Stress Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Defense Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression
Tagcloud ?		abundance apaf cardiomyocytes conversely cyt cytochrome cytosolic damaged degradation e3 engaged glioma knocked ligase likewise mitochondrial mitochondrially myotubes neuroblastoma neurons parc parkin postmitotic proliferating proteasome released survive ubiquitination withstand	3p24 amino assigned bond cdna conjugating drosophila e1 encoding enzyme extension fluorescence formed hybridization identity kb product shares similarity thioester transcribed transcript ubc ubcd2 ubch6 ubch8 ubcm2 ubiquitin
Tagcloud (Difference) ?		abundance apaf cardiomyocytes conversely cyt cytochrome cytosolic damaged degradation e3 engaged glioma knocked ligase likewise mitochondrial mitochondrially myotubes neuroblastoma neurons parc parkin postmitotic proliferating proteasome released survive ubiquitination withstand	3p24 amino assigned bond cdna conjugating drosophila e1 encoding enzyme extension fluorescence formed hybridization identity kb product shares similarity thioester transcribed transcript ubc ubcd2 ubch6 ubch8 ubcm2 ubiquitin
Tagcloud (Intersection) ?