PLXNB3 and CUL7

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		PLXNB3	CUL7
Description		plexin B3	cullin 7
Image		No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Cell Surface Membrane	Anaphase-promoting Complex Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Cullin-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm 3M Complex
	Molecular Function	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding Rho GDP-dissociation Inhibitor Binding Cell-cell Adhesion Mediator Activity	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Nervous System Development Synapse Assembly Regulation Of Cell Shape Negative Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Negative Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Positive Chemotaxis Cell Chemotaxis Semaphorin-plexin Signaling Pathway	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Vasculogenesis Epithelial To Mesenchymal Transition Placenta Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Golgi Organization Regulation Of Mitotic Nuclear Division Insulin Receptor Signaling Pathway Protein Ubiquitination Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Dendrite Morphogenesis
Pathways		Other semaphorin interactions	XBP1(S) activates chaperone genes Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			3M syndrome
GWAS			Appendicular lean mass ( 33097823)
Interacting Genes		10 interacting genes: ARHGEF11 BTBD3 CUL7 CUL9 DSCR9 HSPA13 MAGI2 MAGI3 RIT2 SPOCK2	10 interacting genes: COMMD1 FBXW8 MEGF10 MTDH MTNR1A PLXNB3 RBX1 SKP1 TP53 UBE2M
Entrez ID		5365	9820
HPRD ID		02198	09901
Ensembl ID		ENSG00000198753	ENSG00000044090
Uniprot IDs		A8K920 Q9ULL4	A0A669KBH4 Q14999
PDB IDs			2JNG 7Z8B
Enriched GO Terms of Interacting Partners?		Cullin-RING Ubiquitin Ligase Complex	Cul7-RING Ubiquitin Ligase Complex Nucleotide-excision Repair NEDD8 Transferase Activity SCF Ubiquitin Ligase Complex Negative Regulation Of Mitophagy Regulation Of Proteolysis Cul2-RING Ubiquitin Ligase Complex Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Proteolysis Protein Neddylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cullin Family Protein Binding Molecular Function Activator Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Macroautophagy Copper Ion Binding Regulation Of Mitophagy DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Autophagy Of Mitochondrion Regulation Of Epithelial Cell Apoptotic Process Protein Monoubiquitination Protein Modification By Small Protein Conjugation Mitophagy SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cholesterol Import Interferon-mediated Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Autophagy Of Mitochondrion Regulation Of Neurogenesis Post-translational Protein Modification Apoptotic Process Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Cellular Response To UV Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Catabolic Process Regulation Of Autophagy NEDD8 Conjugating Enzyme Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cellular Response To Insulin Stimulus Regulation Of Protein Catabolic Process Insulin Receptor Signaling Pathway
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