CUL9

Description		cullin 9
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Microtubule Cytoskeleton Organization Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Nuclear Division Protein Ubiquitination
Pathways		Neddylation
Drugs
Diseases
GWAS		Adult hearing difficulty ( 31564434) General risk tolerance (MTAG) ( 30643258) Obesity-related traits ( 23251661) Tea consumption ( 31046077) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: CYCS DSCAM MTDH PLXNB3 TP53 UBE2E2 UBE2G1 UBE2G2 UBE2L3
Entrez ID		23113
HPRD ID		06317
Ensembl ID		ENSG00000112659
Uniprot IDs		Q8IWT3
PDB IDs		2JUF 8Q7E 8Q7H 8RHZ
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Cell-cell Adhesion Mediator Activity Protein K11-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Post-translational Protein Modification Positive Regulation Of Axonogenesis Regulation Of Neurogenesis Protein K63-linked Ubiquitination Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Synapse Assembly Regulation Of Nervous System Development Rho GDP-dissociation Inhibitor Binding Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Apoptosome Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response ISG15 Transferase Activity Positive Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Axonogenesis Central Nervous System Development Negative Regulation Of Catalytic Activity Negative Regulation Of Lamellipodium Assembly Histone Deacetylase Regulator Activity Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of G1/S Transition Of Mitotic Cell Cycle B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Regulation Of G1 To G0 Transition Glial Cell Apoptotic Process Cellular Response To UV-C ATP-dependent DNA/DNA Annealing Activity
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