PLXNB3 and ARHGEF11

Number of citations of the paper that reports this interaction (PMID 12183458)
53

Data Source:
HPRD (two hybrid)

		PLXNB3	ARHGEF11
Gene Name		plexin B3	Rho guanine nucleotide exchange factor (GEF) 11
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Integral Component Of Membrane	Intracellular Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding Rho GDP-dissociation Inhibitor Binding	G-protein Coupled Receptor Binding Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell Adhesion Axon Guidance Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Cell Migration Negative Regulation Of GTPase Activity Positive Chemotaxis Cell Chemotaxis Semaphorin-plexin Signaling Pathway	Cytokinesis Regulation Of Cell Growth Movement Of Cell Or Subcellular Component Striated Muscle Contraction G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Axon guidance Semaphorin interactions Other semaphorin interactions	Signaling by GPCR Signalling by NGF Axon guidance Semaphorin interactions Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ARHGEF11 BTBD3 CUL7 CUL9 MAGI2 MAGI3 RIT2 SPOCK2	13 interactors: ABCA1 CDC42 GNA12 GNA13 LPAR1 LPAR2 MAP1A MAP1B PLXNB1 PLXNB2 PLXNB3 RHOA SLC1A6
Entrez ID		5365	9826
HPRD ID		02198	09302
Ensembl ID		ENSG00000198753	ENSG00000132694
Uniprot IDs		A8K920 B7Z3H9 Q9ULL4	F8W8P9 O15085
PDB IDs			1HTJ 1XCG 2DLS 3KZ1 3T06
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Nervous System Development Cytokinesis Planar Cell Polarity Pathway Involved In Axis Elongation Regulation Of Mitotic Nuclear Division Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Catalytic Activity Generation Of Neurons Neurogenesis Cell Morphogenesis Involved In Differentiation Cell Development Cellular Response To Organic Substance Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Neuron Projection Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Regulation Of Cell Division Negative Regulation Of Activin Receptor Signaling Pathway Signaling Glomerular Visceral Epithelial Cell Development Cell Communication Positive Regulation Of Cell Projection Organization Positive Regulation Of Hydrolase Activity Cell Cycle Process Cell Morphogenesis Positive Regulation Of Phosphoprotein Phosphatase Activity Nerve Growth Factor Signaling Pathway Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Cytoskeleton Organization Regulation Of Catalytic Activity Positive Regulation Of Neuron Differentiation Anatomical Structure Morphogenesis Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Differentiation System Development Response To Organic Substance Positive Regulation Of Receptor Internalization Positive Regulation Of Cellular Metabolic Process Regulation Of Neuron Projection Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Cellular Response To Stimulus Regulation Of Activin Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Positive Regulation Of Neurogenesis Cell Cycle Cell Division Microtubule Cytoskeleton Organization	Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Axonogenesis Positive Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Positive Regulation Of Cell Development Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Neuron Differentiation Regulation Of Rho Protein Signal Transduction Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Movement Regulation Of Neuron Projection Development Regulation Of Axonogenesis Regulation Of Cell Shape Semaphorin-plexin Signaling Pathway Positive Regulation Of Neurogenesis Regulation Of Cell Development Positive Regulation Of Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Rho Protein Signal Transduction Axonogenesis Generation Of Neurons Signaling Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Cell Communication Axon Development Positive Regulation Of Phospholipase Activity Anatomical Structure Morphogenesis Neurogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Differentiation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Neuron Projection Morphogenesis Cell Projection Organization Regulation Of Ras Protein Signal Transduction Regulation Of Neurogenesis Regulation Of Signal Transduction Cell Morphogenesis Involved In Differentiation Ossification Involved In Bone Maturation Signal Transduction Positive Regulation Of Intracellular Signal Transduction Bone Maturation
Tagcloud ?		alias amplifications bgn casp9 ccnc cgh e2f5 eck efnb3 epha2 ercc1 fgf3 fgr frap1 hspg2 il12a l1cam lamc1 mexican nonaffected outline pctk2 pctk3 plexr tnfrsf10a tnfrsf10b tp73 turned underexpressed
Tagcloud (Difference) ?		alias amplifications bgn casp9 ccnc cgh e2f5 eck efnb3 epha2 ercc1 fgf3 fgr frap1 hspg2 il12a l1cam lamc1 mexican nonaffected outline pctk2 pctk3 plexr tnfrsf10a tnfrsf10b tp73 turned underexpressed
Tagcloud (Intersection) ?