PLXNB3 and SPOCK2

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		PLXNB3	SPOCK2
Description		plexin B3	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding Rho GDP-dissociation Inhibitor Binding Cell-cell Adhesion Mediator Activity	Calcium Ion Binding Protein Binding Collagen Binding Glycosaminoglycan Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Nervous System Development Synapse Assembly Regulation Of Cell Shape Negative Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Negative Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Positive Chemotaxis Cell Chemotaxis Semaphorin-plexin Signaling Pathway	Synapse Assembly Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Regulation Of Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Cell Motility
Pathways		Other semaphorin interactions
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Insulin-like growth factors ( 21216879) Response to antioxidants and zinc in age-related macular degeneration (disease progression) ( 33751636) Smoking behavior ( 22832964)
Interacting Genes		10 interacting genes: ARHGEF11 BTBD3 CUL7 CUL9 DSCR9 HSPA13 MAGI2 MAGI3 RIT2 SPOCK2	4 interacting genes: DSCR9 PLXNB3 SPOCK3 TES
Entrez ID		5365	9806
HPRD ID		02198	12146
Ensembl ID		ENSG00000198753	ENSG00000107742
Uniprot IDs		A8K920 Q9ULL4	Q92563
PDB IDs
Enriched GO Terms of Interacting Partners?		Cullin-RING Ubiquitin Ligase Complex	Negative Regulation Of Hydrolase Activity Negative Regulation Of Catalytic Activity Rho GDP-dissociation Inhibitor Binding Semaphorin Receptor Activity Semaphorin Receptor Complex Negative Regulation Of Lamellipodium Assembly Negative Regulation Of GTPase Activity Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Metalloendopeptidase Inhibitor Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Glycosaminoglycan Binding Regulation Of Catalytic Activity Extracellular Matrix Binding
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