IFFO1 and XRCC4

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		IFFO1	XRCC4
Gene Name		intermediate filament family orphan 1	X-ray repair complementing defective repair in Chinese hamster cells 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intermediate Filament	Condensed Chromosome Nucleus Nucleoplasm Centrosome Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Cell Junction DNA Ligase IV Complex Nonhomologous End Joining Complex
	Molecular Function		DNA Binding Protein Binding Protein C-terminus Binding Ligase Activity
	Biological Process		In Utero Embryonic Development Pro-B Cell Differentiation DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Central Nervous System Development Response To X-ray Response To Gamma Radiation Viral Process T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Repair Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Establishment Of Integrated Proviral Latency
Pathways			HIV Life Cycle Nonhomologous End-joining (NHEJ) HIV Infection Integration of provirus Double-Strand Break Repair 2-LTR circle formation Early Phase of HIV Life Cycle
Drugs			S-(Dimethylarsenic)Cysteine
Diseases
GWAS			Hypertension ( 21626137)
Protein-Protein Interactions		5 interactors: ACAP1 GFI1B NDN RNF183 XRCC4	19 interactors: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 FAM9B GZMB IFFO1 LIG4 NBN NHEJ1 PNKP PRKDC VIM
Entrez ID		25900	7518
HPRD ID		09988	15951
Ensembl ID		ENSG00000010295	ENSG00000152422
Uniprot IDs		B4DQQ1 Q0D2I5 Q6P593 Q9Y4M3	Q13426 Q7Z763
PDB IDs			1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03
Enriched GO Terms of Interacting Partners?			Double-strand Break Repair DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Polynucleotide 3' Dephosphorylation Single Strand Break Repair Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Apoptotic Process Programmed Cell Death Cellular Response To Stress B Cell Activation Cell Death Death Pro-B Cell Differentiation Cell Activation Immunoglobulin Production Response To Radiation Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination DNA Recombination Lymphoid Progenitor Cell Differentiation Response To Stress DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Protein Autophosphorylation Regulation Of Voltage-gated Calcium Channel Activity DNA Catabolic Process Response To Ionizing Radiation Isotype Switching Lymphocyte Activation T Cell Differentiation V(D)J Recombination Mitotic Cell Cycle Checkpoint Regulation Of Protein Autophosphorylation Cellular Response To Stimulus Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Leukocyte Activation Regulation Of Cell Cycle Process Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Cycle Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Central Nervous System Development Response To Stimulus Regulation Of Cell Death Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process
Tagcloud ?			annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc5 ybx1 yy1 zfhx3 zfp36 zmat3
Tagcloud (Difference) ?			annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc5 ybx1 yy1 zfhx3 zfp36 zmat3
Tagcloud (Intersection) ?