ZBTB5 and ST3GAL3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZBTB5	ST3GAL3
Gene Name		zinc finger and BTB domain containing 5	ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Golgi Membrane Extracellular Region Integral Component Of Golgi Membrane Golgi Cisterna Membrane
	Molecular Function	DNA Binding Metal Ion Binding	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Carbohydrate Metabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Protein O-linked Glycosylation Pathogenesis O-glycan Processing Keratan Sulfate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process Sialylation
Pathways			Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective MGAT2 causes MGAT2-CDG (CDG-2a) O-linked glycosylation Defective CHST14 causes EDS, musculocontractural type Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases Defective ALG2 causes ALG2-CDG (CDG-1i) Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective EXT2 causes exostoses 2 Signaling by NOTCH Termination of O-glycan biosynthesis Synthesis of substrates in N-glycan biosythesis Asparagine N-linked glycosylation MPS IV - Morquio syndrome A Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Metabolism of carbohydrates O-linked glycosylation of mucins Diseases associated with N-glycosylation of proteins MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective SLC26A2 causes chondrodysplasias Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective PAPSS2 causes SEMD-PA Defective MAN1B1 causes MRT15 MPS IIIA - Sanfilippo syndrome A Pre-NOTCH Expression and Processing Defective ALG11 causes ALG11-CDG (CDG-1p) MPS IIIC - Sanfilippo syndrome C Pre-NOTCH Processing in Golgi Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome
Drugs
Diseases
GWAS			Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728)
Protein-Protein Interactions		8 interactors: CCDC85B DCX JADE2 PPARG PTPN5 ST3GAL3 SWAP70 ZBTB7B	5 interactors: ACTG1 RPL8 SCAMP2 TTR ZBTB5
Entrez ID		9925	6487
HPRD ID		08829	05930
Ensembl ID		ENSG00000168795	ENSG00000126091
Uniprot IDs		O15062 Q5T942	B4DX62 Q11203
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Metformin Response To Diuretic Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Pancreatic Stellate Cell Proliferation Cellular Response To Vitamin E Regulation Of Cholesterol Transporter Activity Regulation Of Fat Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Hyperoxia Receptor Biosynthetic Process Negative Regulation Of Multicellular Organismal Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage Negative Regulation Of Telomerase Activity Negative Regulation Of Growth
Tagcloud ?		ac azol bcor bromide competed corepressor deacetylation diphenyltetrazolium driving finger immunocytochemistry interacted kruppel meth ncor occupying postulated poz proto repressor retinoblastoma sage serial smrt sorter speckles thi yl
Tagcloud (Difference) ?		ac azol bcor bromide competed corepressor deacetylation diphenyltetrazolium driving finger immunocytochemistry interacted kruppel meth ncor occupying postulated poz proto repressor retinoblastoma sage serial smrt sorter speckles thi yl
Tagcloud (Intersection) ?