IP6K1 and DDB1

Number of citations of the paper that reports this interaction (PubMedID 25349427)
50

Data Source:
BioGRID (affinity chromatography technology, pull down)

		IP6K1	DDB1
Description		inositol hexakisphosphate kinase 1	damage specific DNA binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol	Chromosome, Telomeric Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Site Of Double-strand Break Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Inositol-1,3,4,5,6-pentakisphosphate Kinase Activity Inositol Hexakisphosphate Kinase Activity Diphosphoinositol Pentakisphosphate Kinase Activity Inositol Hexakisphosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Inositol 5-diphosphate Pentakisphosphate 5-kinase Activity Diphosphoinositol Tetrakisphosphate Kinase Activity	Nucleic Acid Binding DNA Binding Damaged DNA Binding Protein Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding WD40-repeat Domain Binding Cullin Family Protein Binding Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Inositol Phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Organophosphate Biosynthetic Process Negative Regulation Of Cold-induced Thermogenesis	DNA Repair Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response Spindle Assembly Involved In Female Meiosis Proteasomal Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Viral Release From Host Cell Cellular Response To UV Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Viral Genome Replication Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Rhythmic Process Negative Regulation Of Developmental Process Biological Process Involved In Interaction With Symbiont Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Type I Interferon-mediated Signaling Pathway UV-damage Excision Repair Base-excision Repair, AP Site Formation Via Deaminated Base Removal Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Reproductive Process
Pathways		Synthesis of pyrophosphates in the cytosol Synthesis of IPs in the nucleus	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Hand grip strength ( 29691431) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip index ( 34021172) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 23128233) Intelligence (MTAG) ( 29326435) Parental longevity (mother's age at death or mother's attained age) ( 31484785) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Resting heart rate ( 29769521 27798624) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Ulcerative colitis ( 25082827) Visceral adipose tissue volume ( 34128465)
Interacting Genes		12 interacting genes: ADAMTSL4 CACNA1A CLK1 COPS2 DDB1 EXOSC7 GPS1 PICK1 RAB3IL1 RPL11 UBE4A VIM	54 interacting genes: ABL1 ANXA1 BCAS3 BRAP BRWD3 CCNK CDK12 CNOT2 COPS5 CUL4A CUL4B DCAF11 DCAF8 DDB2 DET1 DNMT3A DNMT3B DTL EME1 ERCC8 H1-2 H3C1 HOXD3 IKZF1 IP6K1 LMO4 MEF2A MTA2 MUS81 PIN1 POLH PPDPF PTEN RASSF1 RBBP4 RBBP7 RNF26 SALL2 SHANK3 SIN3A SKP2 SNAI1 STAT1 SUPT3H TBL1X TBL1XR1 TP73 USP40 VAMP3 WDTC1 WIPI2 XPA ZEB2 ZNF277
Entrez ID		9807	1642
HPRD ID		07379	10952
Ensembl ID		ENSG00000176095	ENSG00000167986
Uniprot IDs		Q92551	Q16531
PDB IDs			2B5L 2B5M 2B5N 2HYE 3E0C 3EI1 3EI2 3EI3 3EI4 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I89 3I8C 3I8E 4A08 4A09 4A0A 4A0B 4A0K 4A0L 4A11 4CI1 4CI2 4CI3 4E54 4E5Z 4TZ4 5FQD 5HXB 5JK7 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6DSZ 6FCV 6H0F 6H0G 6PAI 6Q0R 6Q0V 6Q0W 6R8Y 6R8Z 6R90 6R91 6R92 6SJ7 6TD3 6UD7 6UE5 6UML 6XK9 6ZUE 6ZX9 7LPS 7OKQ 7OO3 7OOB 7OOP 7OPC 7OPD 7U8F 7UKN 7V7B 7V7C 7ZN7 7ZNN 8AJM 8AJN 8AJO 8B3D 8B3F 8B3G 8B3I 8BU1 8BU2 8BU3 8BU4 8BU5 8BU6 8BU7 8BU9 8BUA 8BUB 8BUC 8BUD 8BUE 8BUF 8BUG 8BUH 8BUI 8BUJ 8BUK 8BUL 8BUM 8BUN 8BUO 8BUP 8BUQ 8BUR 8BUS 8BUT 8CVP 8D7U 8D7V 8D7W 8D7X 8D7Y 8D7Z 8D80 8D81 8DEY 8G46 8G66 8OIZ 8OJH 8OV6 8QH5 8ROX 8ROY 8T9A 8TL6 8TNP 8TNQ 8TNR 8TZX 8U15 8U16 8U17 8UH6 8WQR 9BBE 9BBG 9BBH 9BBI 9BZ0 9DHD 9DJT 9DJX 9DQD 9EJQ 9ER2 9FD2 9FJX 9FMR
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Neddylation Protein Deneddylation Protein Neddylation COP9 Signalosome	Cul4-RING E3 Ubiquitin Ligase Complex Nucleoplasm Nucleus Regulation Of Transcription By RNA Polymerase II Cul4A-RING E3 Ubiquitin Ligase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Complex DNA Metabolic Process Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process DNA Repair DNA Damage Response Positive Regulation Of Biosynthetic Process Regulation Of Cell Cycle DNA Binding Response To Stress Protein Modification By Small Protein Conjugation Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Protein Ubiquitination Regulation Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Cell Fate Specification Negative Regulation Of RNA Metabolic Process Histone Binding Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process
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