RAB21 and RABGEF1

Number of citations of the paper that reports this interaction (PMID 17450153)
39

Data Source:
BioGRID (pull down)

		RAB21	RABGEF1
Gene Name		RAB21, member RAS oncogene family	RAB guanine nucleotide exchange factor (GEF) 1
Image
Gene Ontology Annotations	Cellular Component	Endosome Early Endosome Endoplasmic Reticulum Membrane Trans-Golgi Network Focal Adhesion Cytoplasmic Side Of Plasma Membrane Vesicle Membrane Cytoplasmic Vesicle Membrane Cleavage Furrow Golgi Cisterna Membrane Extracellular Vesicular Exosome Cytoplasmic Side Of Early Endosome Membrane	Early Endosome Vesicle Recycling Endosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Intracellular Protein Transport Metabolic Process Regulation Of Exocytosis Regulation Of Endocytosis Rab Protein Signal Transduction Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Leukocyte Migration Protein Targeting To Membrane Endocytosis Protein Ubiquitination Positive Regulation Of Rab GTPase Activity Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Kit Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Aortic root size ( 21223598)
Protein-Protein Interactions		2 interactors: APPL1 RABGEF1	30 interactors: AP1G1 BLOC1S6 CIPC DAZAP2 DGCR6 GGA1 GGA2 HRAS KXD1 L1CAM MON1A MON1B RAB21 RAB33B RAB4A RABEP1 RNF11 RNF168 RPS27A TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBB UBC UBE2D1 UBE2D3 YWHAB ZC2HC1C
Entrez ID		23011	27342
HPRD ID		06695	11477
Ensembl ID			ENSG00000243335
Uniprot IDs		Q9UL25	B4DZM7 Q9UJ41
PDB IDs		1YZT 1YZU 1Z08 1Z0I 2OT3	1TXU 2C7M 2C7N 2OT3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Kit Signaling Pathway Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Mast Cell Activation Involved In Immune Response Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Establishment Of Protein Localization Negative Regulation Of Mast Cell Activation Regulation Of Protein Localization Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Leukocyte Migration Regulation Of Cellular Localization Regulation Of Mast Cell Degranulation Regulation Of Mast Cell Activation Negative Regulation Of Cytokine Secretion Negative Regulation Of Interleukin-6 Production Negative Regulation Of Exocytosis Negative Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Regulated Secretory Pathway Negative Regulation Of Response To Cytokine Stimulus Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Endocytosis Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Glucose Import Regulation Of Cellular Component Organization Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Protein Secretion Regulation Of Glucose Transport Regulation Of Interleukin-6 Production Negative Regulation Of Inflammatory Response Regulation Of Leukocyte Migration Negative Regulation Of Intracellular Transport Positive Regulation Of Rab GTPase Activity Negative Regulation Of Immune Response Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Regulation Of Cytokine Secretion Insulin Receptor Signaling Pathway Regulation Of Exocytosis Negative Regulation Of Leukocyte Activation Protein Targeting To Membrane Negative Regulation Of Secretion By Cell Negative Regulation Of Secretion Negative Regulation Of Protein Transport Regulation Of Endocytosis	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Immune Response Intracellular Transport Of Virus Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Protein Polyubiquitination Intracellular Transport Positive Regulation Of Innate Immune Response Establishment Of Localization In Cell Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Protein Transport Innate Immune Response DNA-templated Transcription, Initiation Cellular Response To Growth Factor Stimulus Negative Regulation Of Type I Interferon Production Viral Protein Processing Response To Growth Factor Establishment Of Protein Localization Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Immune System Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Innate Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Immune Response-regulating Signaling Pathway Cellular Localization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Immune Response Mitotic Cell Cycle Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?		abl adamtsl4 baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii	abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 fbxl2 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Difference) ?		abl adamtsl4 baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii	abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 fbxl2 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Intersection) ?