CEP131 and MAPKAPK2

Number of citations of the paper that reports this interaction (PubMedID 26616734)
48

Data Source:
BioGRID (enzymatic study)

		CEP131	MAPKAPK2
Description		centrosomal protein 131	MAPK activated protein kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Manchette Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Cytoplasmic Vesicle Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Cell Projection Intercellular Bridge Sperm Head-tail Coupling Apparatus	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Ciliary Basal Body Extracellular Exosome
	Molecular Function	Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Spermatogenesis Spermatid Development Sperm Axoneme Assembly Positive Regulation Of Cell Population Proliferation Regulation Of Centrosome Duplication Cell Projection Organization Cell Differentiation Intraciliary Transport Involved In Cilium Assembly Intraciliary Transport Cilium Assembly Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Manchette Assembly Non-motile Cilium Assembly Intramanchette Transport	MAPK Cascade Toll-like Receptor Signaling Pathway Leukotriene Metabolic Process Inflammatory Response DNA Damage Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Response To Cytokine Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Regulation Of MRNA Stability Macropinocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway MRNA Stabilization Inner Ear Development Positive Regulation Of Macrophage Cytokine Production 3'-UTR-mediated MRNA Stabilization Regulation Of Cellular Response To Heat
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	p38MAPK events CREB phosphorylation Synthesis of Leukotrienes (LT) and Eoxins (EX) Oxidative Stress Induced Senescence Regulation of HSF1-mediated heat shock response VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Regulation of TNFR1 signaling
Drugs			Staurosporine 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS		Frontotemporal dementia ( 26154020) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391)	Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		3 interacting genes: MAPKAPK2 YWHAE YWHAZ	42 interacting genes: AGO2 AKT1 ALOX5 ARPC5 ATF1 BAG2 BCL2L1 BECN1 CDC25B CEP131 CREB1 DDX5 DES EEF2K ETV1 HNRNPA0 HSF1 HSPB1 LIMK1 LSP1 MAP2K6 MAPK14 MAPK3 MDM2 PABPC1 PARN PHC2 PIAS2 RCSD1 SHC1 SRF STAT3 TCF3 TH TRIM28 TRIM29 TSC2 UBE2J1 WASF1 YWHAZ ZFP36 ZFP36L1
Entrez ID		22994	9261
HPRD ID		16532	11882
Ensembl ID		ENSG00000141577	ENSG00000162889
Uniprot IDs		I3L2J8 Q9UPN4	P49137
PDB IDs			1KWP 1NXK 1NY3 2JBO 2JBP 2OKR 2ONL 2OZA 2P3G 2PZY 3A2C 3FPM 3FYJ 3FYK 3GOK 3KA0 3KC3 3KGA 3M2W 3M42 3R2B 3R2Y 3R30 3WI6 4TYH 6T8X 6TCA 7NRY 8XU4 8XX1
Enriched GO Terms of Interacting Partners?		Phosphoserine Residue Binding MAPK Cascade Regulation Of Innate Immune Response Protein Sequestering Activity Regulation Of Defense Response Protein Phosphatase Binding Intracellular Signaling Cassette Melanosome Regulation Of Immune Response Transmembrane Transporter Binding Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Heart Rate By Hormone Synaptic Target Recognition Protein Targeting Activation Of Innate Immune Response Protein Domain Specific Binding Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Cellular Response To Stress Positive Regulation Of Innate Immune Response Ubiquitin Protein Ligase Binding Regulation Of Immune System Process Golgi Reassembly Cadherin Binding Regulation Of Calcium Ion Export Across Plasma Membrane Calcium-dependent Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Positive Regulation Of Toll-like Receptor Signaling Pathway Immune System Process Immune Response-activating Signaling Pathway Macropinocytosis Establishment Of Golgi Localization Immune Response-regulating Signaling Pathway Focal Adhesion Extracellular Exosome Activation Of Immune Response Pinocytosis Positive Regulation Of Defense Response Calcium Channel Inhibitor Activity Regulation Of Lysosome Organization Golgi Localization Regulation Of Cellular Response To Heat Negative Regulation Of Immune System Process Antibacterial Innate Immune Response Protein Localization To Endoplasmic Reticulum Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Biological Quality Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Hippo Signaling	Negative Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of RNA Metabolic Process Response To Stress Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Catabolic Process Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Protein Kinase Binding Intracellular Signaling Cassette RNA Stabilization Regulation Of RNA Stability Response To Decreased Oxygen Levels Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression P38MAPK Cascade Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Oxygen Levels Regulation Of Metabolic Process Nucleus Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Post-transcriptional Regulation Of Gene Expression Regulation Of Cell Population Proliferation Regulation Of MRNA Stability Cytosol Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Response To Peptide RNA Metabolic Process Regulation Of MRNA Metabolic Process Animal Organ Development MAPK Cascade Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Response To Epidermal Growth Factor Positive Regulation Of Biosynthetic Process Response To Nutrient Levels Regulation Of Multicellular Organismal Process Negative Regulation Of Autophagy Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Macromolecule Metabolic Process Positive Regulation Of Developmental Process Regulation Of Cellular Component Organization Identical Protein Binding Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Cellular Response To Stress
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?