CEP131

Description		centrosomal protein 131
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Manchette Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Cytoplasmic Vesicle Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Cell Projection Intercellular Bridge Sperm Head-tail Coupling Apparatus
	Molecular Function	Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Spermatogenesis Spermatid Development Sperm Axoneme Assembly Positive Regulation Of Cell Population Proliferation Regulation Of Centrosome Duplication Cell Projection Organization Cell Differentiation Intraciliary Transport Involved In Cilium Assembly Intraciliary Transport Cilium Assembly Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Manchette Assembly Non-motile Cilium Assembly Intramanchette Transport
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Frontotemporal dementia ( 26154020) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391)
Interacting Genes		3 interacting genes: MAPKAPK2 YWHAE YWHAZ
Entrez ID		22994
HPRD ID		16532
Ensembl ID		ENSG00000141577
Uniprot IDs		I3L2J8 Q9UPN4
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphoserine Residue Binding MAPK Cascade Regulation Of Innate Immune Response Protein Sequestering Activity Regulation Of Defense Response Protein Phosphatase Binding Intracellular Signaling Cassette Melanosome Regulation Of Immune Response Transmembrane Transporter Binding Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Heart Rate By Hormone Synaptic Target Recognition Protein Targeting Activation Of Innate Immune Response Protein Domain Specific Binding Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Cellular Response To Stress Positive Regulation Of Innate Immune Response Ubiquitin Protein Ligase Binding Regulation Of Immune System Process Golgi Reassembly Cadherin Binding Regulation Of Calcium Ion Export Across Plasma Membrane Calcium-dependent Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Positive Regulation Of Toll-like Receptor Signaling Pathway Immune System Process Immune Response-activating Signaling Pathway Macropinocytosis Establishment Of Golgi Localization Immune Response-regulating Signaling Pathway Focal Adhesion Extracellular Exosome Activation Of Immune Response Pinocytosis Positive Regulation Of Defense Response Calcium Channel Inhibitor Activity Regulation Of Lysosome Organization Golgi Localization Regulation Of Cellular Response To Heat Negative Regulation Of Immune System Process Antibacterial Innate Immune Response Protein Localization To Endoplasmic Reticulum Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Biological Quality Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Hippo Signaling
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