ARHGAP12

Description		Rho GTPase activating protein 12
Image		No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Cytoplasm Plasma Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding
	Biological Process	Morphogenesis Of An Epithelial Sheet Phagocytosis, Engulfment Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Assembly
Pathways		RAC1 GTPase cycle RHOD GTPase cycle RHOV GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		C-reactive protein levels ( 24763700) Glycine levels ( 30837465) Intraocular pressure ( 31959993) Pulse pressure ( 27841878 28135244) Systolic blood pressure ( 27841878) Uterine fibroids ( 31649266)
Novel Interacting Genes		1 novel interacting genes: IL2RA
Interacting Genes		5 interacting genes: RAC1 SHANK2 SRPK1 SRPK2 TRIP10
Entrez ID		94134
HPRD ID		06446
Ensembl ID		ENSG00000165322
Uniprot IDs		Q1RLN5 Q8IWW6
PDB IDs
Enriched GO Terms of Interacting Partners?		Phagocytic Cup Positive Regulation Of Viral Genome Replication Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Interleukin-2 Receptor Complex Defense Response Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Viral Genome Replication Regulation Of Viral Life Cycle Negative Regulation Of Viral Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of T Cell Homeostatic Proliferation Interleukin-2 Binding Interleukin-2 Receptor Activity Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Regulation Of MRNA Processing Regulation Of Viral Process Nuclear Speck Organization Synaptic Receptor Adaptor Activity Homeostasis Of Number Of Cells Regulation Of Ovarian Follicle Development Cell Cortex Erythrocyte Enucleation Regulation Of RNA Splicing Regulation Of Synaptic Plasticity Auditory Receptor Cell Morphogenesis Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb Protein-RNA Complex Assembly Magnesium Ion Binding Positive Regulation Of Cell Population Proliferation Activation-induced Cell Death Of T Cells Kinocilium G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Postsynaptic Membrane Hepatocyte Growth Factor Receptor Signaling Pathway Activated T Cell Proliferation Regulation Of Neuron Maturation Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering R-loop Processing Positive Regulation Of Bicellular Tight Junction Assembly Regulation Of Interleukin-23 Production
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