RHOT1

Description		ras homolog family member T1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Calcium Ion Binding Protein Binding GTP Binding Hydrolase Activity ATP Hydrolysis Activity GDP Binding Metal Ion Binding
	Biological Process	Mitochondrion Organization Regulation Of Mitochondrion Organization Cellular Homeostasis Mitochondrion Transport Along Microtubule Mitochondrial Outer Membrane Permeabilization
Pathways		Ub-specific processing proteases RHOT1 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Cataracts ( 34127677) High chromosomal aberration frequency (chromosome type) ( 31586183) High chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Obesity-related traits ( 23251661)
Novel Interacting Genes		1 novel interacting genes: SHANK2
Interacting Genes
Entrez ID		55288
HPRD ID		15247
Ensembl ID		ENSG00000126858
Uniprot IDs		H7BXZ6 Q8IXI2
PDB IDs		5KSO 5KSP 5KSY 5KSZ 5KTY 5KU1 6D71
Enriched GO Terms of Interacting Partners?		Synaptic Receptor Adaptor Activity Long-term Synaptic Depression Social Behavior Regulation Of Hippo Signaling Photoreceptor Inner Segment Ciliary Membrane Negative Regulation Of Hippo Signaling Long-term Synaptic Potentiation Negative Regulation Of Synaptic Transmission Vocalization Behavior Ionotropic Glutamate Receptor Binding Neurofilament Brush Border Membrane Photoreceptor Outer Segment Associative Learning Synapse Assembly SH3 Domain Binding Dendritic Spine Positive Regulation Of Synaptic Transmission Adult Behavior Growth Cone Learning Regulation Of Synaptic Plasticity Postsynaptic Membrane Cell Junction Assembly Postsynaptic Density Learning Or Memory Synapse Organization Cognition Neuron Projection Apical Plasma Membrane Neuronal Cell Body
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