KLHL21 and KLC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLHL21	KLC3
Description		kelch like family member 21	kinesin light chain 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Spindle Polar Microtubule Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex	Cytoplasm Mitochondrion Cytoskeleton Kinesin Complex Microtubule Motile Cilium Ciliary Rootlet Neuron Projection
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cullin Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Microtubule Binding Kinesin Binding
	Biological Process	Protein Ubiquitination Regulation Of Cytokinesis Chromosome Passenger Complex Localization To Spindle Midzone Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Division	Microtubule-based Movement Spermatogenesis Spermatid Development Axo-dendritic Transport Cell Differentiation Sperm Mitochondrial Sheath Assembly
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: AURKB CYLD IKBKB KLC3 MAPRE1	41 interacting genes: ABI3 ATP23 BBS5 BICDL2 CBY2 CCNH CENPP CEP57L1 CROCC CT55 DTX2 GEM IHO1 IMP3 KDM1A KIF5A KIF5B KIF5C KLHL21 KRT13 KRT15 MBIP NDC80 NECAB2 NEFL PCBD2 PDE4DIP QARS1 SMARCB1 SNAP47 STX11 TCF4 USHBP1 VPS52 WAC WASHC1 YWHAG YWHAH YWHAQ ZNF417 ZNF572
Entrez ID		9903	147700
HPRD ID		17239	03212
Ensembl ID		ENSG00000162413	ENSG00000104892
Uniprot IDs		Q9UJP4	Q6P597
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoplasmic Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Pattern Recognition Receptor Signaling Pathway Attachment Of Mitotic Spindle Microtubules To Kinetochore Spindle Intracellular Receptor Signaling Pathway Activation Of Innate Immune Response Spindle Midzone Regulation Of Microtubule-based Process Mitotic Spindle Pole Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Innate Immune Response Microtubule Immune Response-activating Signaling Pathway Cytoplasmic Microtubule Canonical NF-kappaB Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Defense Response Negative Regulation Of Interleukin-18-mediated Signaling Pathway Regulation Of Cytoskeleton Organization Met1-linked Polyubiquitin Deubiquitinase Activity Cytoskeleton Spindle Assembly Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Astral Microtubule Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Microtubule Polymerization Or Depolymerization Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Immune Response Centrosome Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Mitotic Sister Chromatid Biorientation Repair Of Mitotic Kinetochore Microtubule Attachment Defect Microtubule Cytoskeleton Organization Involved In Mitosis Protein Localization To Mitotic Spindle Protein Localization To Spindle Microtubule Protein Linear Deubiquitination Negative Regulation Of Intracellular Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent IkappaB Kinase Activity Spindle Pole Mitotic Spindle Astral Microtubule End Cortical Microtubule Cytoskeleton Spindle Organization Microtubule-based Process	Ciliary Rootlet Organelle Localization Establishment Of Organelle Localization Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Anterograde Dendritic Transport Protein Transport Along Microtubule Anterograde Axonal Transport Establishment Of Vesicle Localization Identical Protein Binding Dendritic Transport Vesicle Localization Plus-end-directed Microtubule Motor Activity Axon Cytoplasm Retrograde Axonal Transport Axonal Transport Dendrite Cytoplasm Axo-dendritic Transport Postsynaptic Cytosol Protein Binding Retrograde Neuronal Dense Core Vesicle Transport Transport Along Microtubule Organelle Transport Along Microtubule Synaptic Vesicle Transport Cytoskeleton-dependent Intracellular Transport Cytoskeleton Vesicle Transport Along Microtubule Kinesin Complex Microtubule-based Transport Establishment Of Localization In Cell Dense Core Granule Cytoskeletal Transport Receptor Localization To Synapse Presynapse Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Cytosolic Transport Vesicle Fusion To Plasma Membrane Vesicle Cytoskeletal Trafficking Microtubule Binding Microtubule Motor Activity Intracellular Transport Protein Localization To Synapse Microtubule-based Process Synaptic Vesicle Membrane Organization Intracellular Protein Localization Insulin-like Growth Factor Receptor Binding Establishment Of Protein Localization Intermediate Filament Organization Secretory Granule Localization Protein Localization To Cell Junction Intermediate Filament Cytoskeleton Organization
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