MICB

Gene Name		MHC class I polypeptide-related sequence B
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Antigen Binding Beta-2-microglobulin Binding Natural Killer Cell Lectin-like Receptor Binding
	Biological Process	T Cell Mediated Cytotoxicity Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Oxidative Stress Response To Heat Viral Process Cytolysis Antigen Processing And Presentation Response To Retinoic Acid Natural Killer Cell Mediated Cytotoxicity Gamma-delta T Cell Activation Negative Regulation Of Defense Response To Virus By Host Regulation Of Immune Response
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		AIDS progression ( 19115949) Behcet's disease ( 23001997) Crohn's disease ( 23128233) Dengue shock syndrome ( 22001756) Hodgkin's lymphoma ( 22286212) Metabolic syndrome ( 22399527) Pulmonary function ( 21946350)
Protein-protein Interactions		2 interactors: KLRC4 KLRK1
Entrez ID		4277
HPRD ID		03894
Ensembl ID		ENSG00000204516
Uniprot IDs		A2AC57 F5H7Q8 Q29980 Q861E6
PDB IDs		1JE6 2WY3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Defense Response Cellular Defense Response Natural Killer Cell Activation T Cell Costimulation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Innate Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Response To Stress Regulation Of T Cell Activation Positive Regulation Of Cell Activation
Tagcloud ?		aberrantly allogeneic autologous axis bcsc bcscs cytotoxicity downregulation elusive escape failed infiltrating killer killing limit metastasis mica mir20a nk nkg2d oncogenic promoted restored resultant rich sensitized stimulatory thereby trans