MICB and KLRC4

Number of citations of the paper that reports this interaction (PMID 12133964)
9

Data Source:
HPRD (in vitro)

		MICB	KLRC4
Gene Name		MHC class I polypeptide-related sequence B	killer cell lectin-like receptor subfamily C, member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane	Integral Component Of Membrane
	Molecular Function	Antigen Binding Beta-2-microglobulin Binding Natural Killer Cell Lectin-like Receptor Binding
	Biological Process	T Cell Mediated Cytotoxicity Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Oxidative Stress Response To Heat Viral Process Cytolysis Antigen Processing And Presentation Response To Retinoic Acid Natural Killer Cell Mediated Cytotoxicity Gamma-delta T Cell Activation Negative Regulation Of Defense Response To Virus By Host Regulation Of Immune Response	Cellular Defense Response
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		AIDS progression ( 19115949) Behcet's disease ( 23001997) Crohn's disease ( 23128233) Dengue shock syndrome ( 22001756) Hodgkin's lymphoma ( 22286212) Metabolic syndrome ( 22399527) Pulmonary function ( 21946350)	Behcet's disease ( 23291587)
Protein-Protein Interactions		2 interactors: KLRC4 KLRK1	4 interactors: MICB RAE1 TYROBP ULBP1
Entrez ID		4277	8302
HPRD ID		03894	16008
Ensembl ID		ENSG00000204516	ENSG00000183542
Uniprot IDs		A2AC57 F5H7Q8 Q29980 Q861E6	O43908
PDB IDs		1JE6 2WY3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Defense Response Cellular Defense Response Natural Killer Cell Activation T Cell Costimulation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Innate Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Response To Stress Regulation Of T Cell Activation Positive Regulation Of Cell Activation	Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Leukocyte Activation Cell Activation Innate Immune Response Regulation Of Immune Response Immune Response Regulation Of Immune System Process Defense Response Leukocyte Mediated Immunity Antigen Processing And Presentation Regulation Of Osteoclast Development Gamma-delta T Cell Activation Neutrophil Activation Involved In Immune Response Negative Regulation Of Defense Response To Virus By Host Lymphocyte Activation Macrophage Activation Involved In Immune Response T Cell Mediated Cytotoxicity Immune System Process Viral Process Neutrophil Activation Cytolysis Negative Regulation Of Defense Response To Virus Macrophage Activation Regulation Of Defense Response To Virus By Host T Cell Mediated Immunity Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Cell Surface Receptor Signaling Pathway Cellular Defense Response Natural Killer Cell Activation Response To Stress Nuclear Envelope Organization MRNA Export From Nucleus Regulation Of Osteoclast Differentiation Glucose Transport RNA Export From Nucleus Hexose Transport Regulation Of Defense Response To Virus Response To Stimulus
Tagcloud ?		aberrantly allogeneic autologous axis bcsc bcscs cytotoxicity downregulation elusive escape failed infiltrating killer killing limit metastasis mica mir20a nk nkg2d oncogenic promoted restored resultant rich sensitized stimulatory thereby trans
Tagcloud (Difference) ?		aberrantly allogeneic autologous axis bcsc bcscs cytotoxicity downregulation elusive escape failed infiltrating killer killing limit metastasis mica mir20a nk nkg2d oncogenic promoted restored resultant rich sensitized stimulatory thereby trans
Tagcloud (Intersection) ?