FAN1 and CCR1

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		FAN1	CCR1
Name		FANCD2 and FANCI associated nuclease 1	C-C motif chemokine receptor 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cilium Intercellular Bridge	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Magnesium Ion Binding Nucleic Acid Binding DNA Binding Nuclease Activity Endonuclease Activity Exonuclease Activity Phosphodiesterase I Activity Protein Binding Zinc Ion Binding 5'-3' Exonuclease Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds 5'-flap Endonuclease Activity Metal Ion Binding Flap-structured DNA Binding Ubiquitin-modified Protein Reader Activity	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair DNA Damage Response Interstrand Cross-link Repair	Dendritic Cell Chemotaxis Monocyte Chemotaxis Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Canonical NF-kappaB Signal Transduction Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		Fanconi Anemia Pathway	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
GWAS		Huntington's disease (age at onset) ( 29750799 ) Huntington's disease progression ( 28642124 )	Arthritis (juvenile idiopathic) ( 33106285 ) Aspartate aminotransferase levels ( 33547301 ) Behcet's disease ( 23291587 ) Celiac disease ( 18311140 20190752 22057235 30572963 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Heel bone mineral density ( 30598549 ) Inflammatory bowel disease ( 26192919 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Myocardial infarction ( 33532862 ) Narcolepsy with cataplexy ( 25986216 ) Ulcerative colitis ( 26192919 28067908 )
Novel Interactors		None recorded	14 novel interactors: A4GNT CCL13 CDC25A CTNNB1 DAG1 DDX3Y DNAJB12 DUSP7 GNAI2 HAS3 KRT6A NPM1 PRSS50 PXMP2
Interacting Genes		4 interacting genes: CCR1 DSCR9 PCNA UBC	30 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CREB3 FAN1 GNA14 GRAMD1A JAK1 LETMD1 MBP PLP2 PRNP QSOX1 SNCA STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2
Entrez ID		22909	1230
HPRD ID		17205	03101
Ensembl ID		ENSG00000198690	ENSG00000163823
Uniprot IDs		Q9Y2M0	P32246 Q5U003
PDB IDs		4REA 4REB 4REC 4RI8 4RI9 4RIA 4RIB 4RIC 4RID 4RY3 8S5A 9CG4 9CHM 9CL7 9CMA 9EO1 9EOA 9GY0	7VL8 7VL9 7VLA
GO Terms Enriched among Interactors		Chemokine (C-C Motif) Ligand 5 Binding Chemokine (C-C Motif) Ligand 7 Binding PCNA Complex PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Positive Regulation Of Deoxyribonuclease Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Leading Strand Elongation MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication	CCR Chemokine Receptor Binding Chemokine Activity Chemokine-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Chemotaxis Eosinophil Migration Antimicrobial Humoral Response Cytokine-mediated Signaling Pathway CCR1 Chemokine Receptor Binding Humoral Immune Response Chemotaxis Cell Chemotaxis Cytokine Activity CCR5 Chemokine Receptor Binding Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Inflammatory Response Granulocyte Chemotaxis Myeloid Leukocyte Migration Granulocyte Migration Leukocyte Chemotaxis Regulation Of Locomotion Regulation Of Cell Migration Response To External Biotic Stimulus Cell-cell Signaling Defense Response To Symbiont Regulation Of Cell Motility Monocyte Chemotaxis Defense Response Signaling Defense Response To Other Organism Response To Stress Cell Communication Response To Other Organism Calcium Ion Homeostasis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Calcium Ion Transport Immune Response Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Immune System Process Intracellular Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Leukocyte Chemotaxis