FAN1

Description		FANCD2 and FANCI associated nuclease 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cilium Intercellular Bridge
	Molecular Function	Magnesium Ion Binding Nucleic Acid Binding DNA Binding Nuclease Activity Endonuclease Activity Exonuclease Activity Phosphodiesterase I Activity Protein Binding Zinc Ion Binding 5'-3' Exonuclease Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds 5'-flap Endonuclease Activity Metal Ion Binding Flap-structured DNA Binding Ubiquitin-modified Protein Reader Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair DNA Damage Response Interstrand Cross-link Repair
Pathways		Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Huntington's disease (age at onset) ( 29750799) Huntington's disease progression ( 28642124)
Interacting Genes		4 interacting genes: CCR1 DSCR9 PCNA UBC
Entrez ID		22909
HPRD ID		17205
Ensembl ID		ENSG00000198690
Uniprot IDs		Q9Y2M0
PDB IDs		4REA 4REB 4REC 4RI8 4RI9 4RIA 4RIB 4RIC 4RID 4RY3 8S5A 9CG4 9CHM 9CL7 9CMA 9EO1 9EOA 9GY0
Enriched GO Terms of Interacting Partners?		Chemokine (C-C Motif) Ligand 5 Binding Chemokine (C-C Motif) Ligand 7 Binding PCNA Complex PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Positive Regulation Of Deoxyribonuclease Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Leading Strand Elongation MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication
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