PRPF39 and MBNL1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PRPF39	MBNL1
Description		pre-mRNA processing factor 39	muscleblind like splicing regulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Commitment Complex Nucleus U1 SnRNP U2-type Prespliceosome	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Protein Binding Pre-mRNA 5'-splice Site Binding	RNA Binding Double-stranded RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	MRNA 5'-splice Site Recognition RNA Processing MRNA Processing RNA Splicing	In Utero Embryonic Development MRNA Processing Nervous System Development RNA Splicing Embryonic Limb Morphogenesis Regulation Of RNA Splicing Myoblast Differentiation
Pathways
Drugs
Diseases
GWAS		Lead levels ( 26025379)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Blond vs. brown/black hair color ( 30531825) End-stage renal disease ( 29885931) Fasting glucose ( 34059833) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Infantile hypertrophic pyloric stenosis ( 22306654) Liver enzyme levels (alanine transaminase) ( 33972514) Male-pattern baldness ( 27182965) Prostate cancer ( 29892016) Type 2 diabetes ( 30054458 30297969 32499647) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) White blood cell count ( 32888494)
Interacting Genes		14 interacting genes: BANP CEBPA DHX30 DMRTB1 GTSE1 LARP4 MBNL1 PRRC2B QKI RBM22 RNU1-1 SF1 TOLLIP TRNAU1AP	21 interacting genes: ABI3BP AEN APP BCAS2 BIN1 CEBPA DAB1 DMRTB1 FBXO7 IDH3A ITSN2 PKM PRPF39 QKI RBFOX2 RBPMS RPL21 SNRPA TLE5 UBC ZNHIT3
Entrez ID		55015	4154
HPRD ID		17913	07355
Ensembl ID		ENSG00000185246	ENSG00000152601
Uniprot IDs		Q86UA1	A0A0A0MQX8 C9JP00 Q86VM6 Q9NR56
PDB IDs			3D2N 3D2Q 3D2S 5U6H 5U6L 5U9B
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding Protein Localization To Endosome Cytoplasmic Stress Granule MRNA Cis Splicing, Via Spliceosome RNA Splicing Erythrocyte Apoptotic Process Macrophage Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding MRNA Processing Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Internal N(7)-methylguanine-containing RNA Reader Activity	Regulation Of Astrocyte Differentiation RNA Processing Nucleus RNA Splicing Regulation Of Glial Cell Differentiation Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Gliogenesis MRNA Binding MRNA Processing U1 SnRNP Negative Regulation Of Cell Development Negative Regulation Of Blood Circulation Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Hemopoiesis Positive Regulation Of Glial Cell Differentiation Synaptic Vesicle Endocytosis Lipid Tube Positive Regulation Of Developmental Process Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway RNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Nucleic Acid Binding MRNA Metabolic Process Regulation Of MRNA Processing Internal N(7)-methylguanine-containing RNA Reader Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Presynaptic Endocytosis Vesicle Dendrite Development Macrophage Differentiation Regulation Of RNA Splicing Regulation Of Neuron Differentiation RNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Amyloid Precursor Protein Catabolic Process Lipid Tube Assembly Negative Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Multicellular Organismal Process Acetylcholine Receptor Activator Activity Lipoprotein Particle
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