HSPA4L and PHLDA1

Number of citations of the paper that reports this interaction (PubMedID 17024176)
60

Data Source:
HPRD (in vitro, in vivo)

		HSPA4L	PHLDA1
Description		heat shock protein family A (Hsp70) member 4 like	pleckstrin homology like domain family A member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity ATP Binding ATP-dependent Protein Folding Chaperone	Protein Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Protein Folding Response To Unfolded Protein	Apoptotic Process Positive Regulation Of Apoptotic Process
Pathways		Regulation of HSF1-mediated heat shock response	Interaction between PHLDA1 and AURKA MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Major depressive disorder ( 29317602)	Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Atrial fibrillation ( 29892015 30061737) Blood trace element (Cu levels) ( 23720494) Blood urea nitrogen levels ( 29403010 31152163) Creatinine levels ( 29403010) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Estimated glomerular filtration rate ( 30604766 31152163) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 26831199) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		5 interacting genes: MSRA NEDD8 PAXIP1 PHLDA1 PTEN	43 interacting genes: APP CDPF1 CREBBP CYSRT1 EIF3D F2RL1 FBXO7 HSPA4 HSPA4L KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP5-1 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LGALS13 MDFI NBPF19 NOTCH2NLA PABPC4 PLSCR1 RPL14 TRAF4 TRAF6 TRIM42 TSPAN4
Entrez ID		22824	22822
HPRD ID		07137	05625
Ensembl ID		ENSG00000164070	ENSG00000139289
Uniprot IDs		A0A140VKE7 B4DXT2 B4DZR0 E9PDE8 O95757	Q8WV24
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleoplasm L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Chorion Development Cellular Response To Camptothecin Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Protein Repair Regulation Of Cell Junction Assembly Locomotor Rhythm Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Presynaptic Membrane Organization Schmidt-Lanterman Incisure Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly MLL3/4 Complex Positive Regulation Of Isotype Switching To IgG Isotypes Methionine Metabolic Process Regulation Of Proteolysis Protein Tag Activity Phosphatidylinositol-3-phosphate Phosphatase Activity Prepulse Inhibition Meiotic Spindle Assembly Synapse Maturation Maternal Behavior Myelin Maintenance Negative Regulation Of Epithelial Cell Migration Parental Behavior Regulation Of Isotype Switching To IgG Isotypes Dendritic Spine Morphogenesis	Intermediate Filament Keratin Filament Cytosol Regulation Of JNK Cascade Positive Regulation Of JNK Cascade
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