RASA3 and HCK

Number of citations: 0 (PubMedID 7782336)
Data Source: HPRD (in vitro, in vivo)

		RASA3	HCK
Name		RAS p21 protein activator 3	HCK proto-oncogene, Src family tyrosine kinase
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane	Nucleus Cytoplasm Lysosome Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Caveola Focal Adhesion Cytoplasmic Side Of Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Cell Projection Membrane Raft Anchoring Junction
	Molecular Function	GTPase Activator Activity Calcium Channel Regulator Activity Zinc Ion Binding Metal Ion Binding	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity
	Biological Process	Response To Stress Signal Transduction Platelet Activation Intracellular Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction	Immune System Process Leukocyte Migration Involved In Immune Response Innate Immune Response-activating Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Exocytosis Phagocytosis Response To Stress Inflammatory Response Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Mesoderm Development Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Leukocyte Degranulation Innate Immune Response Respiratory Burst After Phagocytosis Protein Autophosphorylation Regulation Of Inflammatory Response Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Leukocyte Migration Regulation Of DNA-binding Transcription Factor Activity Type II Interferon-mediated Signaling Pathway Cellular Response To Lipid Regulation Of Podosome Assembly
Pathways		Regulation of RAS by GAPs	Nef and signal transduction FCGR activation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling FLT3 signaling through SRC family kinases
Drugs		None	1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Phosphonotyrosine Quercetin Bosutinib Fostamatinib
GWAS		Anti-Epstein-Barr virus IgG seropositivity ( 33204752 ) Cutaneous melanoma or hair colour ( 32341527 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Phoneme awareness ( 30741946 ) Platelet distribution width ( 32888494 ) White blood cell count ( 32888494 ) Whole brain grey matter density ( 31530798 )	Adult body size ( 32376654 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Inflammatory bowel disease ( 23128233 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Migraine ( 27322543 )
Interacting Genes		5 interacting genes: APP FES HCK RACK1 RAP1A	117 interacting genes: ABL1 ABL2 ACTB ADAM15 AGK AGR2 APP AR ARRB1 ASAP1 BCAR1 BCR BPIFA1 BTK CBL CCDC88B CCR3 CD2AP CHST15 CREBBP CSF2RB CSF3R CSK CTAG1A CTAG1B CYB5D2 CYSRT1 DNM2 DOK1 DOK2 EGFR ELMO1 ERBB2 ERBB3 ERBB4 EVL FASLG FCGR1A FCGR2A FHL2 FHL5 GAB1 GOPC GRB14 HNRNPK HSF2BP IL6ST INCA1 INPP5D IRF2BPL KHDRBS1 KIT KPRP KRT31 KRT34 KRT35 KRT36 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-1 LCP2 LETMD1 LMNA MAP4K5 MDK MDM2 MET MID2 MKRN3 MTUS2 NBPF19 NGEF NOTCH2NLA PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 PLEKHG4 PNMA1 PRRG4 RAPGEF1 RASA1 RASA3 RBPMS RPL10 SF3B3 SH2B2 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TEKT4 TEPSIN TNK2 TOX2 TP73 TRIM27 TRIP6 TRPV4 TSG101 UNC119 VAV1 WAS WDCP WIPF1 WNT2 ZSCAN4
Entrez ID		22821	3055
HPRD ID		05537	00796
Ensembl ID		ENSG00000185989	ENSG00000101336
Uniprot IDs		Q14644	A8K4G3 P08631
PDB IDs		Not available	1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 4LUD 4LUE 4ORZ 4U5W 5H09 5H0B 5H0E 5H0G 5H0H 5HCK 5NUH 5ZJ6 8F2P 9BYJ
GO Terms Enriched among Interactors		Regulation Of Vesicle-mediated Transport Regulation Of Endocytosis Regulation Of Phagocytosis Positive Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Transport Positive Regulation Of Phosphate Metabolic Process Cellular Response To Oxygen-containing Compound Response To Nerve Growth Factor Response To Growth Factor Cellular Response To Growth Factor Stimulus Cellular Response To Nerve Growth Factor Stimulus Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Neuron Projection Cellular Response To CAMP Positive Regulation Of Immune System Process Regulation Of Supramolecular Fiber Organization Amyloid-beta Complex Regulation Of Cellular Component Organization Signaling Receptor Binding Growth Cone Lamellipodium Regulation Of Developmental Process Regulation Of Response To Calcium Ion Cell Body Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Protein Polymerization Anchoring Junction Regulation Of Protein-containing Complex Assembly Cellular Response To Lipid Response To CAMP Positive Regulation Of GTPase Activity Regulation Of Biological Quality Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Developmental Process Positive Regulation Of Cellular Component Biogenesis Acetylcholine Receptor Activator Activity Regulation Of Phosphorus Metabolic Process Defense Response To Gram-positive Bacterium Lipoprotein Particle Positive Regulation Of Protein Import Cytoplasmic Side Of Plasma Membrane Regulated Exocytosis Positive Regulation Of Hydrolase Activity Response To Antineoplastic Agent IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Protein Autophosphorylation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway SH3 Domain Binding Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Endocytosis Intracellular Signaling Cassette Cytosol Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Supramolecular Fiber Organization Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Keratin Filament Immune Response-regulating Signaling Pathway Protein Tyrosine Kinase Activity ERBB Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Immune System Process Protein Binding Regulation Of Signal Transduction Antigen Receptor-mediated Signaling Pathway Phosphotyrosine Residue Binding Intermediate Filament Regulation Of Immune System Process Plasma Membrane Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction Immune Response-activating Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Negative Regulation Of Programmed Cell Death Cell-cell Junction Developmental Process Regulation Of Cell Motility Regulation Of Immune Response Actin Filament Organization Activation Of Immune Response Regulation Of Cell Communication Regulation Of Signaling Response To Growth Factor Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Locomotion Identical Protein Binding Endocytosis