RAB40B and WFDC1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RAB40B	WFDC1
Description		RAB40B, member RAS oncogene family	WAP four-disulfide core domain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ruffle Nuclear Envelope Cytoplasm Endosome Cytosol Plasma Membrane Synaptic Vesicle Membrane Lamellipodium Lamellipodium Membrane Cell Projection Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Exocytosis Protein Ubiquitination Positive Regulation Of Cell Migration Negative Regulation Of Actin Filament Bundle Assembly Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Lamellipodium Organization Cellular Detoxification	Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Inflammatory Response Negative Regulation Of Wound Healing
Pathways		RAB geranylgeranylation
Drugs
Diseases
GWAS		Colorectal cancer or advanced adenoma ( 30510241)	Blood protein levels ( 30072576) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Systolic blood pressure (alcohol consumption interaction) ( 24376456) Systolic blood pressure (baseline) ( 33603002) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		10 interacting genes: ANKRD27 APP CRYAA EFEMP2 FHIT FHL3 RAP2A RAP2B RAP2C WFDC1	5 interacting genes: EZR FOSL1 RAB40B XRCC2 ZNF677
Entrez ID		10966	58189
HPRD ID		11472	05614
Ensembl ID		ENSG00000141542	ENSG00000103175
Uniprot IDs		Q12829	Q9HC57
PDB IDs
Enriched GO Terms of Interacting Partners?		Rap Protein Signal Transduction Bounding Membrane Of Organelle Recycling Endosome Cytoplasmic Vesicle Membrane GDP Binding Endomembrane System G Protein Activity Recycling Endosome Membrane Endosome Establishment Of Endothelial Intestinal Barrier Regulation Of Protein Tyrosine Kinase Activity Cell-cell Contact Zone Establishment Of Endothelial Barrier Endothelial Cell Development Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Adenylylsulfatase Activity Adenylylsulfate-ammonia Adenylyltransferase Activity Diadenosine Triphosphate Catabolic Process Regulation Of Dendrite Morphogenesis Small GTPase-mediated Signal Transduction Tertiary Granule Membrane Positive Regulation Of Smooth Muscle Cell-matrix Adhesion GTPase Activity Negative Regulation Of Cell Migration Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Intracellular Signaling Cassette Cell Development Lipoprotein Particle Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Protein Import GTP Binding Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Negative Regulation Of SNARE Complex Assembly PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Cell Migration Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
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