ABHD17A and GPC4

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		ABHD17A	GPC4
Description		abhydrolase domain containing 17A, depalmitoylase	glypican 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Endosome Membrane Postsynaptic Density Membrane Nuclear Speck Cell Projection Dendritic Spine Synapse Postsynaptic Membrane Recycling Endosome Membrane Postsynaptic Density Membrane Postsynaptic Recycling Endosome Membrane Glutamatergic Synapse	Extracellular Region Nucleus Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Lysosomal Lumen Synapse Extracellular Exosome Side Of Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Palmitoyl-(protein) Hydrolase Activity Hydrolase Activity	Protein Binding Coreceptor Activity
	Biological Process	Protein Depalmitoylation NLRP3 Inflammasome Complex Assembly Protein Localization To Membrane Regulation Of Postsynapse Organization Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Protein Localization To Microtubule Positive Regulation Of Protein Localization To Endosome	Regulation Of Signal Transduction Wnt Signaling Pathway Cell Migration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synaptic Membrane Adhesion Regulation Of Presynapse Assembly
Pathways		RAS processing	Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs
Diseases
GWAS
Interacting Genes		14 interacting genes: BIRC2 DLG4 EHMT2 GOLGA2 GPC4 HPGDS KRTAP5-9 MDFI PLSCR4 PNMA1 RGS20 TNIP1 TRAF1 TRIM27	10 interacting genes: ABHD17A ACP5 AKAP9 CCNC COL18A1 FGF2 PICK1 PTEN PTPRD PTPRF
Entrez ID		81926	2239
HPRD ID		07475	02160
Ensembl ID		ENSG00000129968	ENSG00000076716
Uniprot IDs		Q96GS6	O75487
PDB IDs
Enriched GO Terms of Interacting Partners?			Presynaptic Membrane Organization Presynaptic Membrane Assembly Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Phosphoprotein Phosphatase Activity Synaptic Membrane Adhesion Regulation Of Response To Wounding Dendritic Spine Organization Identical Protein Binding System Development Nervous System Development Neuron Projection Organization Response To Electrical Stimulus Postsynapse Organization Negative Regulation Of Superoxide Anion Generation Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Cell-cell Signaling Cell Communication Signaling Membrane Organization Postsynaptic Density Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly Chondroitin Sulfate Proteoglycan Binding Response To Stress Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Wound Healing Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Neuron Projection Trans-synaptic Signaling Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Synaptic Signaling Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Regulation Of Neurogenesis Protein Dephosphorylation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Angiogenesis Involved In Coronary Vascular Morphogenesis Regulation Of Organ Growth Regulation Of Retinal Cell Programmed Cell Death Lymphatic Endothelial Cell Migration
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