DKK4

Description		dickkopf Wnt signaling pathway inhibitor 4
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Co-receptor Binding Receptor Antagonist Activity
	Biological Process	Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Hair Follicle Placode Formation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants
Drugs
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: NRG1
Interacting Genes		3 interacting genes: GIMAP5 ITGAM TSPO2
Entrez ID		27121
HPRD ID		05660
Ensembl ID		ENSG00000104371
Uniprot IDs		Q9UBT3
PDB IDs		5O57
Enriched GO Terms of Interacting Partners?		ErbB-3 Class Receptor Binding Positive Regulation Of Peptidyl-tyrosine Autophosphorylation ERBB2-ERBB4 Signaling Pathway Integrin Binding Endocardial Cell Differentiation Nickel Cation Binding Integrin AlphaM-beta2 Complex Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Neutrophil Degranulation Response To Curcumin Complement-mediated Synapse Pruning Negative Regulation Of Catecholamine Metabolic Process Vertebrate Eye-specific Patterning Ectodermal Cell Differentiation 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Protein Autophosphorylation ERBB4-ERBB4 Signaling Pathway Regulation Of Neutrophil Degranulation Response To Gram-positive Bacterium Enucleate Erythrocyte Differentiation Activation Of Protein Kinase B Activity ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Synapse Pruning Cardiac Muscle Cell Myoblast Differentiation Complement Component C3b Binding Ventricular Trabecula Myocardium Morphogenesis Cardioblast Differentiation Regulation Of Protein Autophosphorylation Complement Receptor Mediated Signaling Pathway Protein Tyrosine Kinase Activator Activity Stem Cell Development Mammary Gland Development Positive Regulation Of Heart Growth Endothelial Cell Differentiation Heart Trabecula Morphogenesis Cardiac Muscle Cell Differentiation Myoblast Differentiation Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Peripheral Nervous System Development Negative Regulation Of Striated Muscle Cell Apoptotic Process Neural Crest Cell Development ERBB2 Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Secretion
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