FCN2 and MASP2

Number of citations of the paper that reports this interaction (PMID 12421953)
7

Data Source:
HPRD (in vitro)

		FCN2	MASP2
Gene Name		ficolin (collagen/fibrinogen domain containing lectin) 2	mannan-binding lectin serine peptidase 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	Antigen Binding Protein Binding Proteoglycan Binding Calcium-dependent Protein Binding Mannan Binding	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Calcium-dependent Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Complement Activation Opsonization Recognition Of Apoptotic Cell Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Complement Activation, Lectin Pathway Proteolysis Complement Activation Complement Activation, Classical Pathway Innate Immune Response
Pathways		Creation of C4 and C2 activators Complement cascade Ficolins bind to repetitive carbohydrate structures on the target cell surface Initial triggering of complement Lectin pathway of complement activation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: MASP1 MASP2	3 interactors: FCN2 MBL2 SERPING1
Entrez ID		2220	10747
HPRD ID		03376	05484
Ensembl ID		ENSG00000160339	ENSG00000009724
Uniprot IDs		Q15485	O00187
PDB IDs		2J0G 2J0H 2J0Y 2J1G 2J2P 2J3F 2J3G 2J3O 2J3U 2J61	1Q3X 1SZB 1ZJK 3TVJ 4FXG
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Complement Activation Protein Activation Cascade Humoral Immune Response Positive Regulation Of Immune Response Innate Immune Response Regulation Of Immune Response Negative Regulation Of Complement Activation Positive Regulation Of Immune System Process Regulation Of Complement Activation Immune Response Regulation Of Immune System Process Defense Response Proteolysis Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Immune System Process Complement Activation, Classical Pathway Negative Regulation Of Immune Response Humoral Immune Response Mediated By Circulating Immunoglobulin Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Stress Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Inflammatory Response Receptor-mediated Endocytosis Negative Regulation Of Protein Processing Negative Regulation Of Immune System Process Regulation Of Protein Processing	Complement Activation Complement Activation, Lectin Pathway Protein Activation Cascade Opsonization Humoral Immune Response Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Regulation Of Immune System Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Defense Response Defense Response To Bacterium Vesicle-mediated Transport Negative Regulation Of Complement Activation, Lectin Pathway Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Phagocytosis Leukocyte Mediated Immunity Adaptive Immune Response Immune System Process Recognition Of Apoptotic Cell Killing By Host Of Symbiont Cells Response To Bacterium Negative Regulation Of Complement Activation Blood Coagulation, Intrinsic Pathway Phagocytosis, Recognition Endocytosis Response To Other Organism Response To Biotic Stimulus Killing Of Cells Of Other Organism Response To Stress Negative Regulation Of Growth Of Symbiont In Host Fibrinolysis Regulation Of Complement Activation Apoptotic Cell Clearance Interaction With Symbiont Defense Response To Gram-negative Bacterium Negative Regulation Of Innate Immune Response Acute-phase Response Positive Regulation Of Phagocytosis Regulation Of Humoral Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Phagocytosis Negative Regulation Of Wound Healing
Tagcloud ?		algorithm carcinoma centralities cluster communicating constructed cxcl14 esr1 experiment genome helped hepatitis hepatocellular holding network networks nodes obtain relevance rfx5 selected significance sub ten top understand value virus wide	2d apoa1 apoa4 biochemistry bioinformatic cfhr1 clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur
Tagcloud (Difference) ?		algorithm carcinoma centralities cluster communicating constructed cxcl14 esr1 experiment genome helped hepatitis hepatocellular holding network networks nodes obtain relevance rfx5 selected significance sub ten top understand value virus wide	2d apoa1 apoa4 biochemistry bioinformatic cfhr1 clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur
Tagcloud (Intersection) ?