FCN2 and MASP1

Number of citations of the paper that reports this interaction (PMID 12421953)
7

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		FCN2	MASP1
Gene Name		ficolin (collagen/fibrinogen domain containing lectin) 2	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
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Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space
	Molecular Function	Antigen Binding Protein Binding Proteoglycan Binding Calcium-dependent Protein Binding Mannan Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Complement Activation Opsonization Recognition Of Apoptotic Cell Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Complement Activation, Lectin Pathway Proteolysis Receptor-mediated Endocytosis Complement Activation Innate Immune Response Negative Regulation Of Complement Activation
Pathways		Creation of C4 and C2 activators Complement cascade Ficolins bind to repetitive carbohydrate structures on the target cell surface Initial triggering of complement Lectin pathway of complement activation Innate Immune System	Creation of C4 and C2 activators Complement cascade Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors Initial triggering of complement Lectin pathway of complement activation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: MASP1 MASP2	15 interactors: C2 C3 FCN2 GADD45A GSK3B H2AFX MAPK6 MAPK8IP2 MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1L
Entrez ID		2220	5648
HPRD ID		03376	02749
Ensembl ID		ENSG00000160339	ENSG00000127241
Uniprot IDs		Q15485	P48740
PDB IDs		2J0G 2J0H 2J0Y 2J1G 2J2P 2J3F 2J3G 2J3O 2J3U 2J61	3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Complement Activation Protein Activation Cascade Humoral Immune Response Positive Regulation Of Immune Response Innate Immune Response Regulation Of Immune Response Negative Regulation Of Complement Activation Positive Regulation Of Immune System Process Regulation Of Complement Activation Immune Response Regulation Of Immune System Process Defense Response Proteolysis Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Immune System Process Complement Activation, Classical Pathway Negative Regulation Of Immune Response Humoral Immune Response Mediated By Circulating Immunoglobulin Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Stress Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Inflammatory Response Receptor-mediated Endocytosis Negative Regulation Of Protein Processing Negative Regulation Of Immune System Process Regulation Of Protein Processing	Complement Activation Protein Activation Cascade Humoral Immune Response Innate Immune Response Regulation Of Immune System Process Regulation Of Immune Response Defense Response Response To Stress Positive Regulation Of Immune System Process Regulation Of Complement Activation Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Immune Response Positive Regulation Of Phagocytosis Regulation Of Humoral Immune Response Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Response To External Stimulus Negative Regulation Of Cellular Protein Metabolic Process Immune Response Regulation Of Phagocytosis Positive Regulation Of Apoptotic Cell Clearance Complement Activation, Lectin Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Acute Inflammatory Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Immune System Process Regulation Of Protein Metabolic Process Leukocyte Mediated Immunity Opsonization Regulation Of Apoptotic Cell Clearance Adaptive Immune Response Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Signal Complex Assembly Positive Regulation Of Endocytosis Response To Stimulus Cell Morphogenesis Involved In Differentiation Axon Guidance Negative Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Processing Neuron Projection Development Cell Projection Morphogenesis Negative Regulation Of Cellular Metabolic Process Cell Part Morphogenesis Regulation Of Phosphorus Metabolic Process Cellular Response To Stress
Tagcloud ?		algorithm carcinoma centralities cluster communicating constructed cxcl14 esr1 experiment genome helped hepatitis hepatocellular holding network networks nodes obtain relevance rfx5 selected significance sub ten top understand value virus wide	accessibility adding attribute biocompatibility biodegradability bioengineered biomaterial clavipes combines desired doxorubicin enabling engineering functionalization functionalized h2 hybrids impede internalized loaded ms1 reasonable silk silks sphere spheres spider tag unless
Tagcloud (Difference) ?		algorithm carcinoma centralities cluster communicating constructed cxcl14 esr1 experiment genome helped hepatitis hepatocellular holding network networks nodes obtain relevance rfx5 selected significance sub ten top understand value virus wide	accessibility adding attribute biocompatibility biodegradability bioengineered biomaterial clavipes combines desired doxorubicin enabling engineering functionalization functionalized h2 hybrids impede internalized loaded ms1 reasonable silk silks sphere spheres spider tag unless
Tagcloud (Intersection) ?