FCN2

Description		ficolin 2
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space External Side Of Plasma Membrane Extracellular Matrix Extracellular Exosome Blood Microparticle Symbiont Cell Surface Serine-type Endopeptidase Complex
	Molecular Function	Antigen Binding Signaling Receptor Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity Identical Protein Binding Proteoglycan Binding Metal Ion Binding Calcium-dependent Protein Binding Lipoteichoic Acid Immune Receptor Activity Carbohydrate Derivative Binding Mannan Binding
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Proteolysis Complement Activation Opsonization Zymogen Activation Killing Of Cells Of Another Organism Recognition Of Apoptotic Cell Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Maturation Positive Regulation Of Opsonization
Pathways		Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)
Interacting Genes		2 interacting genes: MASP1 MASP2
Entrez ID		2220
HPRD ID		03376
Ensembl ID		ENSG00000160339
Uniprot IDs		Q15485
PDB IDs		2J0G 2J0H 2J0Y 2J1G 2J2P 2J3F 2J3G 2J3O 2J3U 2J61 4NYT 4R9J 4R9T
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Zymogen Activation Complement Activation Calcium-dependent Protein Binding Serine-type Peptidase Activity Killing Of Cells Of Another Organism Serine-type Endopeptidase Activity Protein Processing Cell Killing Humoral Immune Response Complement Component C4b Binding Protein Maturation Immune Effector Process Activation Of Immune Response Peptidase Activity Calcium Ion Binding Innate Immune Response Positive Regulation Of Immune Response Negative Regulation Of Complement Activation Complement Activation, Alternative Pathway Defense Response To Symbiont Defense Response To Other Organism Regulation Of Complement Activation Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Other Organism Complement Activation, Classical Pathway Immune Response Proteolysis Regulation Of Humoral Immune Response Response To External Biotic Stimulus Defense Response Extracellular Space Hydrolase Activity Regulation Of Immune System Process Identical Protein Binding Immune System Process Extracellular Region Negative Regulation Of Immune Response Protein Metabolic Process Response To Stress
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