JAZF1 and NR2C2

Number of citations of the paper that reports this interaction (PMID 15302918)
14

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		JAZF1	NR2C2
Gene Name		JAZF zinc finger 1	nuclear receptor subfamily 2, group C, member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcriptional Repressor Complex	Nucleoplasm
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity Metal Ion Binding	Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Spermatogenesis Nervous System Development Gene Expression Cerebellum Development Cell Differentiation Positive Regulation Of Embryonic Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Behavior Meiotic Cell Cycle
Pathways			Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS		Crohn's disease ( 23128233) Height ( 20881960 19343178 23563607 18952825) Prostate cancer ( 18264096) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Type 2 diabetes ( 18372903 20581827)	Alcohol and nictotine co-dependence ( 22488850)
Protein-Protein Interactions		3 interactors: NR2C2 PPARG RXRA	21 interactors: AR CD2AP CDC37 CHUK ESR1 FKBP5 HDAC4 HNF4A HSP90AA1 HSP90AB1 IKBKB ITSN2 JAZF1 KDM1A NR2C1 NR2C2AP PEBP1 RXRB TAB1 TAB2 TRAF2
Entrez ID		221895	7182
HPRD ID		09373	03253
Ensembl ID		ENSG00000153814
Uniprot IDs		Q86VZ6	F2YGU2 P49116 Q6PHZ7
PDB IDs			3P0U
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Hormone Stimulus Response To Lipid Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Response To Hormone Response To Retinoic Acid Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Metformin Response To Diuretic Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Pancreatic Stellate Cell Proliferation Single Organism Reproductive Process Reproductive Process Positive Regulation Of Transcription, DNA-templated Placenta Development Intracellular Receptor Signaling Pathway Cellular Response To Vitamin E Positive Regulation Of Translational Initiation By Iron Regulation Of Cholesterol Transporter Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Hyperoxia Receptor Biosynthetic Process Negative Regulation Of Multicellular Organismal Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage Negative Regulation Of Telomerase Activity Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Branching Involved In Prostate Gland Morphogenesis Response To Organic Substance Reproductive Structure Development Positive Regulation Of Cellular Metabolic Process Cellular Response To Prostaglandin E Stimulus	Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Innate Immune Response I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor 4 Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Hormone-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 5 Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Signaling Toll-like Receptor 2 Signaling Pathway Response To Organic Substance Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Regulation Of Immune Response Regulation Of Metabolic Process MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Immune Response Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway
Tagcloud ?		aberration distinction endometrial ess fam22 federation girth guiding gynecology hgus hguss hysterectomy identifiable immunomarker lymphadenectomy meetings multidisciplinary obstetrics oophorectomy peritoneum preferential rearrangement resemble salpingo sarcomas staged stroma undifferentiated ywhae
Tagcloud (Difference) ?		aberration distinction endometrial ess fam22 federation girth guiding gynecology hgus hguss hysterectomy identifiable immunomarker lymphadenectomy meetings multidisciplinary obstetrics oophorectomy peritoneum preferential rearrangement resemble salpingo sarcomas staged stroma undifferentiated ywhae
Tagcloud (Intersection) ?