OTUD1 and PRDX4

Number of citations of the paper that reports this interaction (PubMedID 36357400)
56

Data Source:
BioGRID (enzymatic study)

		OTUD1	PRDX4
Description		OTU deubiquitinase 1	peroxiredoxin 4
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GO Annotations	Cellular Component		Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Peroxiredoxin Activity Molecular Adaptor Activity Molecular Sequestering Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process	Proteolysis Protein Deubiquitination Protein K63-linked Deubiquitination	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Extracellular Matrix Organization Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Protein Maturation Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway	Neutrophil degranulation
Drugs
Diseases
GWAS		Obesity (early onset extreme) ( 23563609) Tourette syndrome ( 30818990)
Interacting Genes		7 interacting genes: AKT1 CARD9 DCAF10 PRDX4 RIPK1 UBC YAP1	27 interacting genes: A1BG ALG12 APOB CDR1 CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 OTUD1 PLG PRDX1 PRDX3 PTBP2 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN
Entrez ID		220213	10549
HPRD ID		19512	05935
Ensembl ID		ENSG00000165312	ENSG00000123131
Uniprot IDs		Q5VV17	Q13162 V9HW63
PDB IDs		4BOP	2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP 8EKW 8EKY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Lymphocyte Apoptotic Process T Cell Apoptotic Process Peptidyl-serine Phosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Organ Growth Negative Regulation Of Apoptotic Signaling Pathway Response To Ketone Negative Regulation Of Cilium Assembly Leukocyte Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Modification Process Apoptotic Signaling Pathway Protein Phosphorylation Regulation Of TRNA Methylation Enterocyte Differentiation Response To Oxidative Stress Phosphorylation Regulation Of Apoptotic Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Regulation Of Cilium Assembly Positive Regulation Of Protein Localization To Endoplasmic Reticulum Cytokine-mediated Signaling Pathway Regulation Of Notch Signaling Pathway Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Positive Regulation Of Gene Expression Protein Autophosphorylation TRNA (guanine-N7)-methylation Regulation Of Organ Growth Response To Tumor Necrosis Factor Cellular Response To Rapamycin Positive Regulation Of Defense Response Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Endodeoxyribonuclease Activity Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Localization To Nucleus Catabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6-mediated Signaling Pathway Positive Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Ripoptosome Assembly Death Domain Binding Ripoptosome Assembly Involved In Necroptotic Process	Blood Microparticle Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Extracellular Space Complement Component C3b Binding Detection Of Molecule Of Bacterial Origin Response To Oxidative Stress Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Hemostasis Regulation Of Blood Coagulation Protein Tag Activity Regulation Of Fibrinolysis Hydrogen Peroxide Catabolic Process Extracellular Exosome Mature Chylomicron Sterol Metabolic Process Cholesterol Metabolic Process Response To External Biotic Stimulus Cholesterol 26-hydroxylase Activity Cholestanetetraol 26-dehydrogenase Activity Bile Acid Metabolic Process Alcohol Catabolic Process Lipopolysaccharide Binding Detection Of Biotic Stimulus Response To Lipopolysaccharide Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Regulation Of Wound Healing Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Symbiont-containing Vacuole Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation NADH-dependent Peroxiredoxin Activity Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity Biological Process Involved In Interaction With Symbiont Response To Molecule Of Bacterial Origin
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