OTUD1 and DCAF10

Number of citations of the paper that reports this interaction (PubMedID 33898171)
58

Data Source:
BioGRID (enzymatic study)

		OTUD1	DCAF10
Description		OTU deubiquitinase 1	DDB1 and CUL4 associated factor 10
Image			No pdb structure
GO Annotations	Cellular Component		Nucleoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Protein Binding
	Biological Process	Proteolysis Protein Deubiquitination Protein K63-linked Deubiquitination	Protein Ubiquitination
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway	Neddylation
Drugs
Diseases
GWAS		Obesity (early onset extreme) ( 23563609) Tourette syndrome ( 30818990)	High light scatter reticulocyte count ( 32888494) Loneliness (linear analysis) ( 27629369) Reticulocyte count ( 32888494)
Interacting Genes		7 interacting genes: AKT1 CARD9 DCAF10 PRDX4 RIPK1 UBC YAP1	7 interacting genes: ADRB2 CUL4B LHX4 OTUD1 SRPK2 TCEA2 UBC
Entrez ID		220213	79269
HPRD ID		19512	08319
Ensembl ID		ENSG00000165312	ENSG00000122741
Uniprot IDs		Q5VV17	A0A0A0MQT4 Q5QP82
PDB IDs		4BOP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Lymphocyte Apoptotic Process T Cell Apoptotic Process Peptidyl-serine Phosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Organ Growth Negative Regulation Of Apoptotic Signaling Pathway Response To Ketone Negative Regulation Of Cilium Assembly Leukocyte Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Modification Process Apoptotic Signaling Pathway Protein Phosphorylation Regulation Of TRNA Methylation Enterocyte Differentiation Response To Oxidative Stress Phosphorylation Regulation Of Apoptotic Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Regulation Of Cilium Assembly Positive Regulation Of Protein Localization To Endoplasmic Reticulum Cytokine-mediated Signaling Pathway Regulation Of Notch Signaling Pathway Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Positive Regulation Of Gene Expression Protein Autophosphorylation TRNA (guanine-N7)-methylation Regulation Of Organ Growth Response To Tumor Necrosis Factor Cellular Response To Rapamycin Positive Regulation Of Defense Response Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Endodeoxyribonuclease Activity Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Localization To Nucleus Catabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6-mediated Signaling Pathway Positive Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Ripoptosome Assembly Death Domain Binding Ripoptosome Assembly Involved In Necroptotic Process
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