FABP1 and PPARA

Number of citations of the paper that reports this interaction (PMID 11226238)
73

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		FABP1	PPARA
Gene Name		fatty acid binding protein 1, liver	peroxisome proliferator-activated receptor alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Peroxisomal Matrix Cytosol Apical Cortex Extracellular Vesicular Exosome	Nucleus Nucleoplasm
	Molecular Function	Chromatin Binding Long-chain Fatty Acid Transporter Activity Fatty Acid Binding Phospholipid Binding Drug Binding Antioxidant Activity Bile Acid Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Drug Binding Zinc Ion Binding Lipid Binding Phosphatase Binding Protein Domain Specific Binding Ubiquitin Conjugating Enzyme Binding Protein Complex Binding Sequence-specific DNA Binding NFAT Protein Binding MDM2/MDM4 Family Protein Binding
	Biological Process	Positive Regulation Of Cell Proliferation Long-chain Fatty Acid Transport Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Intestinal Absorption Positive Regulation Of Hydrolase Activity Cellular Response To Hydrogen Peroxide Cellular Response To Hypoxia	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Metabolic Process Heart Development Circadian Rhythm Epidermis Development Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Fatty Acid Transport Intracellular Receptor Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Protein Binding Negative Regulation Of Appetite Response To Insulin Circadian Regulation Of Gene Expression Behavioral Response To Nicotine Wound Healing Lipoprotein Metabolic Process Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fatty Acid Oxidation Enamel Mineralization Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Neuron Death Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Nuclear Receptor transcription pathway REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
Drugs			Clofibrate Fenofibrate Gemfibrozil Bezafibrate Deoxy-Bigchap 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid ALEGLITAZAR
Diseases
GWAS
Protein-Protein Interactions		5 interactors: FLNA GRB2 PPARA PPARG SNTA1	44 interactors: AIP AKAP13 CDK3 CEP350 CHD9 DAP3 DUT EP300 FABP1 FOXA3 GADD45A GADD45B GADD45G HELZ2 HSP90AA1 MAPK1 MAPK3 MECR MED1 MED24 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR1H3 NRBF2 NRIP1 POU1F1 PPARGC1A PPARGC1B PRKCA PRKCD PRMT1 PRMT8 RELA RXRA RXRG SIRT1 SRC STAC3 SUMO1 TNP1 UBE2I
Entrez ID		2168	5465
HPRD ID		00612	01369
Ensembl ID		ENSG00000163586	ENSG00000186951
Uniprot IDs		P07148 Q05CP7 Q6FGL7	F1D8S4 Q07869
PDB IDs		2F73 2L67 2L68 2LKK 2PY1 3B2H 3B2I 3B2J 3B2K 3B2L 3STK 3STM 3STN 3VG2 3VG3 3VG4 3VG5 3VG6 3VG7	1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage Positive Regulation Of Fatty Acid Oxidation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process Negative Regulation Of Lipid Storage Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Oxidation Response To Insulin Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Lipid Storage Fatty Acid Transport Response To Peptide Hormone Response To Peptide Regulation Of Cellular Ketone Metabolic Process Receptor Metabolic Process Regulation Of Fatty Acid Metabolic Process Tissue Development Cellular Response To Hormone Stimulus Regulation Of Lipid Transport Wound Healing Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Response To Metformin Low-density Lipoprotein Particle Receptor Biosynthetic Process Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Pancreatic Stellate Cell Proliferation Response To Diuretic Regulation Of Vasoconstriction By Circulating Norepinephrine Response To Wounding Monocarboxylic Acid Transport Hormone-mediated Signaling Pathway Response To Alkaloid Response To Organonitrogen Compound Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cholesterol Transporter Activity Cellular Response To Vitamin E Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Blood Pressure Cellular Response To Steroid Hormone Stimulus Response To Hormone Placenta Development Platelet Activation Intracellular Receptor Signaling Pathway Cellular Response To Insulin Stimulus Epithelium Development DNA-templated Transcription, Initiation Response To Abiotic Stimulus	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Transcription, DNA-templated Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Response To Hormone DNA-templated Transcription, Initiation Organelle Organization Regulation Of Gene Expression Cellular Response To Organic Substance Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Chromatin Modification Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Response To Organic Substance Peptidyl-amino Acid Modification Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Androgen Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Regulation Of Signaling Signal Transduction Response To Steroid Hormone Negative Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Cell Communication Nucleobase-containing Compound Metabolic Process
Tagcloud ?		a1c adipocytes albuminuria ap2 capillaries ectopic excretion fabp4 filtration glomerular glomerulus hba1c independently measurable participated peritubular predicts proteinuria sobetsu systolic tanno tertile triglycerides u uacr undetectable urinary yearly	abca1 alfalfa aragonesa breed concentrate contrary dams finishing grazed grazing indoors lambs lengths lpl lt pparg rasa scarb1 sf slaughtering srebp1 subcutaneous supplemented thoracis tocopherol tocopheryl ve10d ve20d ve30d
Tagcloud (Difference) ?		a1c adipocytes albuminuria ap2 capillaries ectopic excretion fabp4 filtration glomerular glomerulus hba1c independently measurable participated peritubular predicts proteinuria sobetsu systolic tanno tertile triglycerides u uacr undetectable urinary yearly	abca1 alfalfa aragonesa breed concentrate contrary dams finishing grazed grazing indoors lambs lengths lpl lt pparg rasa scarb1 sf slaughtering srebp1 subcutaneous supplemented thoracis tocopherol tocopheryl ve10d ve20d ve30d
Tagcloud (Intersection) ?