F9

Gene Name		coagulation factor IX
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding
	Biological Process	Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Blood Coagulation, Extrinsic Pathway Peptidyl-glutamic Acid Carboxylation Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Intrinsic Pathway Post-translational protein modification Extrinsic Pathway Removal of aminoterminal propeptides from gamma-carboxylated proteins Formation of Fibrin Clot (Clotting Cascade) Gamma-carboxylation of protein precursors Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Antihemophilic Factor Menadione
Diseases
GWAS
Protein-protein Interactions		5 interactors: F2 F7 F8 GGCX LRP1
Entrez ID		2158
HPRD ID		02385
Ensembl ID		ENSG00000101981
Uniprot IDs		P00740
PDB IDs		1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamic Acid Carboxylation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Protein Activation Cascade Response To Wounding Blood Coagulation, Intrinsic Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Positive Regulation Of Blood Coagulation Acute-phase Response Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Blood Coagulation Beta-amyloid Clearance Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Response To Vitamin K Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification Platelet Activation Protein Metabolic Process Blood Coagulation, Extrinsic Pathway Response To Stress Negative Regulation Of Fibrinolysis Proteolysis Regulation Of Phospholipase A2 Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Fibrinolysis Inflammatory Response Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Platelet Activation Positive Regulation Of Cholesterol Efflux Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Lipoprotein Transport Positive Regulation Of Cholesterol Transport Regulation Of Cholesterol Efflux Response To Stimulus Aorta Morphogenesis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Regulation Of Cell Migration Aorta Development Regulation Of Astrocyte Differentiation Fibrinolysis
Tagcloud ?		abundance achieved apparatus availability class contains decreases developmental differentiate dramatic embryogenesis embryonal endoderm feature find involves multisubunit murine parietal patterns polymerase regulation sl1 substantial tafi48 tafi95 tafs tata transcription