F9 and F8

Number of citations of the paper that reports this interaction (PMID 11830468)
20

Data Source:
HPRD (in vitro)

		F9	F8
Gene Name		coagulation factor IX	coagulation factor VIII, procoagulant component
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding	Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding Oxidoreductase Activity
	Biological Process	Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Blood Coagulation, Extrinsic Pathway Peptidyl-glutamic Acid Carboxylation Post-translational Protein Modification Cellular Protein Metabolic Process	Platelet Degranulation Proteolysis Acute-phase Response Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation Oxidation-reduction Process
Pathways		Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Intrinsic Pathway Post-translational protein modification Extrinsic Pathway Removal of aminoterminal propeptides from gamma-carboxylated proteins Formation of Fibrin Clot (Clotting Cascade) Gamma-carboxylation of protein precursors Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Common Pathway Intrinsic Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)
Drugs		Antihemophilic Factor Menadione	Drotrecogin alfa Coagulation Factor IX
Diseases
GWAS			Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Red blood cell traits ( 23446634)
Protein-Protein Interactions		5 interactors: F2 F7 F8 GGCX LRP1	16 interactors: ASGR2 CALR CANX F10 F2 F9 GGA1 HSPA5 LMAN1 LRP1 MCFD2 PHYH PROC PROS1 UBQLN1 VWF
Entrez ID		2158	2157
HPRD ID		02385	02384
Ensembl ID		ENSG00000101981	ENSG00000185010
Uniprot IDs		P00740	P00451
PDB IDs		1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5	1CFG 1D7P 1FAC 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 3J2Q 3J2S 4BDV
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamic Acid Carboxylation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Protein Activation Cascade Response To Wounding Blood Coagulation, Intrinsic Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Positive Regulation Of Blood Coagulation Acute-phase Response Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Blood Coagulation Beta-amyloid Clearance Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Response To Vitamin K Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification Platelet Activation Protein Metabolic Process Blood Coagulation, Extrinsic Pathway Response To Stress Negative Regulation Of Fibrinolysis Proteolysis Regulation Of Phospholipase A2 Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Fibrinolysis Inflammatory Response Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Platelet Activation Positive Regulation Of Cholesterol Efflux Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Lipoprotein Transport Positive Regulation Of Cholesterol Transport Regulation Of Cholesterol Efflux Response To Stimulus Aorta Morphogenesis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Regulation Of Cell Migration Aorta Development Regulation Of Astrocyte Differentiation Fibrinolysis	Post-translational Protein Modification Peptidyl-glutamic Acid Carboxylation Blood Coagulation Hemostasis Blood Coagulation, Intrinsic Pathway Regulation Of Body Fluid Levels Wound Healing Peptidyl-amino Acid Modification Vesicle-mediated Transport Response To Wounding Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Protein Metabolic Process Blood Coagulation, Extrinsic Pathway Protein Activation Cascade Negative Regulation Of Blood Coagulation Platelet Activation Negative Regulation Of Coagulation Glycoprotein Metabolic Process Negative Regulation Of Wound Healing Response To Stress Platelet Degranulation Regulation Of Blood Coagulation Protein Glycosylation Macromolecule Glycosylation Glycosylation Cellular Protein Modification Process Receptor-mediated Endocytosis Regulation Of Wound Healing Cellular Protein Metabolic Process Glycoprotein Biosynthetic Process Establishment Of Localization In Cell Response To Endoplasmic Reticulum Stress Fibrinolysis Secretion By Cell Proteolysis Transport Leukocyte Migration Cellular Localization Regulation Of Cell Migration Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Regulation Of Cell Motility Chaperone-mediated Protein Folding Secretion Peptide Antigen Assembly With MHC Class I Protein Complex Beta-amyloid Clearance Regulation Of Protein Folding In Endoplasmic Reticulum Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Endocytosis
Tagcloud ?		abundance achieved apparatus availability class contains decreases developmental differentiate dramatic embryogenesis embryonal endoderm feature find involves multisubunit murine parietal patterns polymerase regulation sl1 substantial tafi48 tafi95 tafs tata transcription	absent ba betac csf f3 gm gmr gmralpha gmrbeta granulocyte heterodimeric magnitude mitogenesis next phenylalanine phosphorylaiton proliferate prominent regenerate residues restored shc shp2 stat5 sufficient tyrosine y577 y612 y695
Tagcloud (Difference) ?		abundance achieved apparatus availability class contains decreases developmental differentiate dramatic embryogenesis embryonal endoderm feature find involves multisubunit murine parietal patterns polymerase regulation sl1 substantial tafi48 tafi95 tafs tata transcription	absent ba betac csf f3 gm gmr gmralpha gmrbeta granulocyte heterodimeric magnitude mitogenesis next phenylalanine phosphorylaiton proliferate prominent regenerate residues restored shc shp2 stat5 sufficient tyrosine y577 y612 y695
Tagcloud (Intersection) ?