ST14 and PHB1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		ST14	PHB1
Description		ST14 transmembrane serine protease matriptase	prohibitin 1
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Early Endosome Plasma Membrane Cell Surface Membrane Mitochondrial Prohibitin Complex Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Complement Component C3a Binding Complement Component C3b Binding Transcription Corepressor Activity Protein Binding Enzyme Binding Proteinase Activated Receptor Binding Histone Deacetylase Binding Protein Heterodimerization Activity
	Biological Process	Neural Tube Closure Proteolysis Protein Catabolic Process Keratinocyte Differentiation Epithelial Cell Differentiation Animal Organ Development Epithelial Cell Morphogenesis Involved In Placental Branching	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Positive Regulation Of Immunoglobulin Production Regulation Of DNA-templated Transcription Mitochondrion Organization Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Growth Positive Regulation Of Interleukin-17 Production RIG-I Signaling Pathway Epigenetic Regulation Of Gene Expression B Cell Activation Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Complement Activation Symbiont Entry Into Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Progesterone Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-6 DNA Biosynthetic Process T-helper 17 Type Immune Response Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Pathways		Formation of the cornified envelope Formation of the cornified envelope	RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Processing of SMDT1 Signaling downstream of RAS mutants
Drugs		Urokinase Benzamidine Camostat	Rocaglamide Didesmethylrocaglamide
Diseases		Ichthyosis with hypotrichosis
GWAS		Adverse response to drug ( 30420678) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		16 interacting genes: AKT1 APC CASP8 CDCP1 CDKN2C CHEK2 F2RL1 HGF PDGFC PHB1 PLAU RAD51 RGS16 SPINT1 STK11 TGFB1	27 interacting genes: ANXA2 BCAS3 CASC3 CCL5 CD40LG COX6C E2F1 ESR1 HDAC1 LONRF3 MAP1LC3A MAP3K10 MCM2 NCOR1 PTEN RAF1 RB1 RBL1 RBL2 SEC22A SIN3A SMARCA2 SMARCA4 ST14 SUMO4 TP53 XPO1
Entrez ID		6768	5245
HPRD ID		06005	01454
Ensembl ID		ENSG00000149418	ENSG00000167085
Uniprot IDs		Q9Y5Y6	A8K401 P35232 Q53FV0
PDB IDs		1EAW 1EAX 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO 4JYT 4JZ1 4JZI 4O97 4O9V 4R0I 5LYO 6N4T 6T9T 8G1V 8G1W	8RRH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Motility Regulation Of Cell Cycle Phase Transition Cell Population Proliferation Regulation Of Cell Cycle Regulation Of Locomotion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Programmed Cell Death Response To Ionizing Radiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Growth Response To Glycoside Cellular Response To Radiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of ERK1 And ERK2 Cascade Response To Stress Regulation Of Cell Growth Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Population Proliferation Cellular Response To Ionizing Radiation Positive Regulation Of Protein Localization Response To Radiation Positive Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Innate Immune Response Negative Regulation Of Growth Negative Regulation Of Intracellular Signal Transduction Anoikis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Defense Response Positive Regulation Of MAPK Cascade	Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Transcription Regulator Complex Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromatin Regulation Of Primary Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Enzyme Binding Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Heterochromatin Formation Rhythmic Process Transcription Repressor Complex Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Epigenetic Regulation Of Gene Expression Circadian Behavior Promoter-specific Chromatin Binding Regulation Of Stem Cell Population Maintenance Negative Regulation Of Gene Expression Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of MiRNA Transcription
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