ST14 and RGS16

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ST14	RGS16
Description		ST14 transmembrane serine protease matriptase	regulator of G protein signaling 16
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding
	Biological Process	Neural Tube Closure Proteolysis Protein Catabolic Process Keratinocyte Differentiation Epithelial Cell Differentiation Animal Organ Development Epithelial Cell Morphogenesis Involved In Placental Branching	G Protein-coupled Receptor Signaling Pathway Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Formation of the cornified envelope Formation of the cornified envelope	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs		Urokinase Benzamidine Camostat
Diseases		Ichthyosis with hypotrichosis
GWAS		Adverse response to drug ( 30420678) Pre-treatment viral load in HIV-1 infection ( 31219150)	Chronotype ( 26955885 27494321 30696823) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600 26955885 27494321) Sleep traits (multi-trait analysis) ( 27992416)
Interacting Genes		16 interacting genes: AKT1 APC CASP8 CDCP1 CDKN2C CHEK2 F2RL1 HGF PDGFC PHB1 PLAU RAD51 RGS16 SPINT1 STK11 TGFB1	14 interacting genes: CREB3L2 CSK EGFR GDE1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAT1 LYN SRC ST14
Entrez ID		6768	6004
HPRD ID		06005	03945
Ensembl ID		ENSG00000149418	ENSG00000143333
Uniprot IDs		Q9Y5Y6	O15492
PDB IDs		1EAW 1EAX 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO 4JYT 4JZ1 4JZI 4O97 4O9V 4R0I 5LYO 6N4T 6T9T 8G1V 8G1W	2BT2 2IK8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Motility Regulation Of Cell Cycle Phase Transition Cell Population Proliferation Regulation Of Cell Cycle Regulation Of Locomotion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Programmed Cell Death Response To Ionizing Radiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Growth Response To Glycoside Cellular Response To Radiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of ERK1 And ERK2 Cascade Response To Stress Regulation Of Cell Growth Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Population Proliferation Cellular Response To Ionizing Radiation Positive Regulation Of Protein Localization Response To Radiation Positive Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Innate Immune Response Negative Regulation Of Growth Negative Regulation Of Intracellular Signal Transduction Anoikis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Defense Response Positive Regulation Of MAPK Cascade	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway GTPase Activity Nucleotide Binding GTP Binding G Protein Activity Plasma Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Regulation Of ERK1 And ERK2 Cascade Membrane Protein Tyrosine Kinase Activity Adenylate Cyclase Regulator Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Protein Localization To Cell Periphery T Cell Costimulation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Signaling Receptor Activator Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity GDP Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Protein Localization To Cell Periphery Signal Transduction Regulation Of Cell Communication Regulation Of Protein Localization Regulation Of Signaling Phototransduction, Visible Light Regulation Of Catalytic Activity Extracellular Exosome Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Tyrosine Kinase Activator Activity Response To Peptide Hormone Response To Hormone Ciliary Basal Body Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Transport Regulation Of MAPK Cascade G Protein-coupled Acetylcholine Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ERBB2 Signaling Pathway
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