SIX2 and EYA1

Number of citations of the paper that reports this interaction (PMID 11734542)
26

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SIX2	EYA1
Gene Name		SIX homeobox 2	EYA transcriptional coactivator and phosphatase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Nuclear Membrane	Nucleus Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Complex Binding Sequence-specific DNA Binding	RNA Binding Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Kidney Development Chondrocyte Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Protein Import Into Nucleus Mesodermal Cell Fate Specification Cell Proliferation Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Cell Migration Regulation Of Ossification Regulation Of Chondrocyte Differentiation Middle Ear Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Nephron Development Nephron Morphogenesis Mesenchymal Stem Cell Maintenance Involved In Nephron Morphogenesis Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Mesenchymal Stem Cell Proliferation Positive Regulation Of Chondrocyte Proliferation	Establishment Of Mitotic Spindle Orientation Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis Double-strand Break Repair Transcription, DNA-templated Pattern Specification Process Sensory Perception Of Sound Anatomical Structure Morphogenesis Response To Ionizing Radiation Striated Muscle Tissue Development Histone Dephosphorylation Protein Sumoylation Cellular Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Peptidyl-tyrosine Dephosphorylation Aorta Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Regulation Of Neuron Differentiation Positive Regulation Of DNA Repair Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Specification Embryonic Skeletal System Morphogenesis Semicircular Canal Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Pharyngeal System Development Lung Epithelial Cell Differentiation Otic Vesicle Morphogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Cochlea Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs
Diseases
GWAS		Metabolite levels ( 21909109)	Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Sleepiness ( 17903308)
Protein-Protein Interactions		5 interactors: AES APP EYA1 EYA3 TLE1	7 interactors: DACH1 GNAI2 GNAZ GSK3B SIX1 SIX2 SIX3
Entrez ID		10736	2138
HPRD ID		05408	03388
Ensembl ID		ENSG00000170577	ENSG00000104313
Uniprot IDs		Q8TBA2 Q9NPC8	A6NCB9 Q99502
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone Dephosphorylation Regulation Of Anoikis Anatomical Structure Morphogenesis Positive Regulation Of DNA Repair RNA Metabolic Process Response To Radiation Gene Expression Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus Multicellular Organismal Development Notch Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Regulation Of Protein Binding Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Regulation Of Gene Expression Anatomical Structure Development Synaptic Growth At Neuromuscular Junction Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Peptidyl-tyrosine Dephosphorylation Collateral Sprouting In Absence Of Injury Negative Regulation Of Wnt Signaling Pathway Developmental Process Organ Morphogenesis Nitrogen Compound Metabolic Process Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Positive Regulation Of Anoikis Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Protein Dephosphorylation Neurological System Process Negative Regulation Of Signaling Organ Development Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis	Protein Localization To Organelle Negative Regulation Of Biosynthetic Process Protein Localization To Nucleus Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Cell Proliferation Mesenchyme Development Middle Ear Morphogenesis Cell Proliferation Nucleocytoplasmic Transport Nuclear Transport Cell Migration Regulation Of Transcription From RNA Polymerase II Promoter Cell Fate Commitment Cell Motility Stem Cell Differentiation Embryonic Organ Morphogenesis Developmental Induction Negative Regulation Of Cellular Metabolic Process Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Locomotion Nephron Morphogenesis Positive Regulation Of Cellular Metabolic Process Pattern Specification Process Embryonic Organ Development Positive Regulation Of Transcription, DNA-templated Neuroblast Migration Mesenchymal Stem Cell Proliferation Cellular Protein Localization Cell Fate Specification Epithelial Cell Differentiation Kidney Morphogenesis Regulation Of Neuron Differentiation Metanephros Development Movement Of Cell Or Subcellular Component Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Stem Cell Proliferation Axis Specification Sensory Organ Development Positive Regulation Of Gene Expression Protein Import Into Nucleus Nuclear Import Ear Morphogenesis Regulation Of Cell Differentiation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development
Tagcloud ?		amphiphysin bmp7 bred cited1 e13 e15 endowment ensures eya1 gammah2ax hypo lhx1 mdm mesenchyme metanephroi nephrogenic nephron npc organogenesis patchy pax2 pax8 pockets renewing sall1 superficially susceptibile thinning wnt4	amphiphysin bmp7 bred cited1 e13 e15 endowment ensures gammah2ax hypo lhx1 mdm mesenchyme metanephroi nephrogenic nephron npc organogenesis patchy pax2 pax8 pockets renewing sall1 six2 superficially susceptibile thinning wnt4
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		amphiphysin bmp7 bred cited1 e13 e15 endowment ensures eya1 gammah2ax hypo lhx1 mdm mesenchyme metanephroi nephrogenic nephron npc organogenesis patchy pax2 pax8 pockets renewing sall1 six2 superficially susceptibile thinning wnt4