SIX2

Description		SIX homeobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Metanephros Development Kidney Development Chondrocyte Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Mesodermal Cell Fate Specification Cell Population Proliferation Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Cell Migration Regulation Of Ossification Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Regulation Of Chondrocyte Differentiation Middle Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Nephron Development Nephron Morphogenesis Mesenchymal Stem Cell Maintenance Involved In Nephron Morphogenesis Condensed Mesenchymal Cell Proliferation Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Mesenchymal Stem Cell Proliferation Positive Regulation Of Chondrocyte Proliferation
Pathways		Formation of the ureteric bud
Drugs
Diseases
GWAS		Blood sugar levels ( 29403010) Clozapine-induced myocarditis in schizophrenia ( 32066683) Fasting blood glucose ( 29621232 33842983) Fasting plasma glucose ( 25187374) Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Lung cancer ( 28604730) Metabolite levels ( 21909109) Refractive error ( 32231278) Retinal arteriole-to-venule ratio ( 31597446)
Interacting Genes		7 interacting genes: APP CDKN2A CLIP4 EYA1 EYA3 TLE1 TLE5
Entrez ID		10736
HPRD ID		05408
Ensembl ID		ENSG00000170577
Uniprot IDs		Q8TBA2 Q9NPC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H2AXY142 Phosphatase Activity Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Stress Regulation Of Anoikis Amyloid Fibril Formation Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Signal Transduction Protein Sumoylation Regulation Of Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Signaling Pathway Ligase Inhibitor Activity Otic Vesicle Morphogenesis Response To Interleukin-1 Response To Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Protein Tyrosine Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Apoptotic Process Nucleus Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization
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