EXT2 and PFDN1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		EXT2	PFDN1
Description		exostosin glycosyltransferase 2	prefoldin subunit 1
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane UDP-N-acetylglucosamine Transferase Complex Extracellular Exosome Catalytic Complex	Cytoplasm Prefoldin Complex Protein-containing Complex
	Molecular Function	Protein Binding Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Polysaccharide Biosynthetic Process Ossification Mesoderm Formation Chondrocyte Differentiation Glycosaminoglycan Biosynthetic Process Protein Glycosylation Protein N-linked Glycosylation Regulation Of Blood Pressure Gene Expression Heparan Sulfate Proteoglycan Biosynthetic Process Heparin Proteoglycan Biosynthetic Process Fluid Transport Vasodilation Cellular Response To Fibroblast Growth Factor Stimulus Multicellular Organismal-level Water Homeostasis Sulfation Sodium Ion Homeostasis Heart Contraction Endochondral Bone Morphogenesis	Protein Folding Negative Regulation Of Amyloid Fibril Formation
Pathways		HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases		Multiple exostoses Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Refractive error ( 32231278)	Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)
Interacting Genes		10 interacting genes: ANXA7 CDKN1A EXT1 GALNT5 GSKIP PFDN1 SMN1 TK1 TRAP1 UBC	55 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEBPA CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		2132	5201
HPRD ID		00599	05357
Ensembl ID		ENSG00000151348	ENSG00000113068
Uniprot IDs		Q93063	O60925
PDB IDs		7SCH 7SCJ 7SCK 7UQX 7UQY 7ZAY	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Glycosaminoglycan Biosynthetic Process Negative Regulation Of Kinase Activity Protein Kinase Inhibitor Activity PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Wound Healing Negative Regulation Of Protein Kinase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Lymphocyte Adhesion To Endothelial Cell Of High Endothelial Venule Glycosaminoglycan Metabolic Process Mesenchymal Cell Differentiation Involved In Bone Development Stomach Development Perichondral Bone Morphogenesis Sweat Gland Development Smoothened Signaling Pathway Involved In Lung Development Heparan Sulfate N-acetylglucosaminyltransferase Activity Thymidine Kinase Activity Translational Attenuation Epithelial Cell Differentiation Negative Regulation Of Protein Phosphorylation Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity DNA Synthesis Involved In Mitotic DNA Replication Kinase Regulator Activity Protein Kinase Binding Protein O-linked Glycosylation Unfolded Protein Binding Negative Regulation Of Phosphorylation Carbohydrate Derivative Biosynthetic Process Cellular Response To Cell-matrix Adhesion Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Oncogene-induced Cell Senescence Stress-induced Premature Senescence Negative Regulation Of Protein Metabolic Process Response To Heparin Embryonic Skeletal Joint Development Protein Glycosylation Limb Joint Morphogenesis Glycosylation Macromolecule Glycosylation Heparin Proteoglycan Biosynthetic Process Chondrocyte Hypertrophy Endochondral Bone Morphogenesis Hematopoietic Stem Cell Migration To Bone Marrow Prefoldin Complex Thymidine Metabolic Process Thymidine Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Intrinsic Apoptotic Signaling Pathway	Positive Regulation Of Microtubule Nucleation Structural Constituent Of Cytoskeleton Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Microtubule Nucleation Nuclear Matrix Positive Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Double-strand Break Repair Intracellular Protein Localization Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Glutamate Receptor Binding Regulation Of Cellular Component Organization
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