EPRS and POU2F1

Number of citations of the paper that reports this interaction (PMID 9537509)
21

Data Source:
BioGRID (two hybrid, pull down, far western blotting)

		EPRS	POU2F1
Gene Name		glutamyl-prolyl-tRNA synthetase	POU class 2 homeobox 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex GAIT Complex	Nucleus Nucleoplasm Transcription Factor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Glutamate-tRNA Ligase Activity Proline-tRNA Ligase Activity Protein Binding ATP Binding RNA Stem-loop Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Protein Complex Assembly Gene Expression Negative Regulation Of Translation Cellular Response To Interferon-gamma	Transcription From RNA Polymerase III Promoter Gene Expression Olfactory Placode Formation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lens Induction In Camera-type Eye
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation
Drugs		L-Glutamic Acid L-Proline \'5\'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine 5\'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine \'5\'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine
Diseases
GWAS			Liver enzyme levels ( 18940312)
Protein-Protein Interactions		12 interactors: AIMP2 ARL4D DUS2 EEF1D HSP90AA1 IARS NEDD4 NELFCD POU2F1 RARS SYNCRIP TAB1	50 interactors: AES APP AR BARD1 BRCA1 CEBPE CREB1 EPRS ESR1 FDXR HCFC1 HMGA1 HMGB2 HNF1A HOXB13 HOXC9 IRF9 LIFR MNAT1 MSX1 NCOR2 NFYA NPAT NR3C1 PARP1 PBX1 PGR PKNOX1 PLK3 POGZ POU2AF1 PRKACA PRKDC RARA RELA RXRA SNAPC4 SOX2 SP1 SP4 STAT5A STAT5B TBP THRA TLE4 TLX2 TNF TXNRD1 VDR XRCC6
Entrez ID		2058	5451
HPRD ID		00703	01250
Ensembl ID		ENSG00000136628	ENSG00000143190
Uniprot IDs		P07814	J3KP77 P14859
PDB IDs		1FYJ 4HVC	1CQT 1E3O 1GT0 1HF0 1O4X 1OCT 1POG 1POU
Enriched GO Terms of Interacting Partners?		TRNA Metabolic Process TRNA Aminoacylation For Protein Translation TRNA Aminoacylation RNA Metabolic Process NcRNA Metabolic Process Nitrogen Compound Metabolic Process Translation Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Respiratory System Development Nucleobase-containing Compound Metabolic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Isoleucyl-tRNA Aminoacylation Cellular Amino Acid Metabolic Process Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein Import Into Mitochondrial Outer Membrane Osteoblast Differentiation Viral Process Negative Regulation Of Cellular Metabolic Process CRD-mediated MRNA Stabilization Arginyl-tRNA Aminoacylation Progesterone Receptor Signaling Pathway Olfactory Placode Formation Immune Response Negative Regulation Of Gene Expression Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Type II Pneumocyte Differentiation Negative Regulation Of Biosynthetic Process Cell Differentiation Positive Regulation Of Metabolic Process Glucocorticoid Receptor Signaling Pathway Activation Of MAPKKK Activity Intracellular Receptor Signaling Pathway Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Lens Induction In Camera-type Eye Macromolecule Biosynthetic Process Heart Morphogenesis Positive Regulation Of Cellular Metabolic Process Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport	Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Gland Development Negative Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organ Development Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Response To Hormone DNA-templated Transcription, Initiation Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Response To Steroid Hormone Organ Morphogenesis Reproductive Process Hormone-mediated Signaling Pathway Anatomical Structure Morphogenesis Intracellular Receptor Signaling Pathway Multicellular Organismal Development System Development
Tagcloud ?		adequate analgesic analgesics assessments caution codeine comparative documentation dying electronic feasible healthcare hospitalised instrument intensity interpretation limitation morphine norwegian old oldest pain palliative paracetamol regard resident retrospective workers young	build built compendium connected controlling databases delineate deoxyribonuclease encode experimentally footprinting gata3 hnf1b hypersensitivity klf4 locations matrices motifs orthologs rarb runx2 rxra silico smad3 sp1 sp3 umod upstream uromodulin
Tagcloud (Difference) ?		adequate analgesic analgesics assessments caution codeine comparative documentation dying electronic feasible healthcare hospitalised instrument intensity interpretation limitation morphine norwegian old oldest pain palliative paracetamol regard resident retrospective workers young	build built compendium connected controlling databases delineate deoxyribonuclease encode experimentally footprinting gata3 hnf1b hypersensitivity klf4 locations matrices motifs orthologs rarb runx2 rxra silico smad3 sp1 sp3 umod upstream uromodulin
Tagcloud (Intersection) ?