SPCS2 and STMN3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SPCS2	STMN3
Gene Name		signal peptidase complex subunit 2 homolog (S. cerevisiae)	stathmin-like 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytoplasm Golgi Apparatus Axon Growth Cone Neuron Projection
	Molecular Function	Peptidase Activity	Tubulin Binding Protein Domain Specific Binding
	Biological Process	Translation Signal Peptide Processing Proteolysis SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Cellular Protein Metabolic Process Regulation Of Insulin Secretion	Microtubule Depolymerization Nervous System Development Regulation Of Microtubule Polymerization Or Depolymerization Cytoplasmic Microtubule Organization Neuron Projection Development Regulation Of Rac GTPase Activity Negative Regulation Of Rac Protein Signal Transduction Regulation Of Cytoskeleton Organization
Pathways		Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Translation Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS			Prostate cancer ( 23535732) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		5 interactors: ATP13A2 CLN8 EGFR STMN3 TEFM	5 interactors: GLP1R NKX3-1 SPCS2 TRPC5 UBQLN1
Entrez ID		9789	50861
HPRD ID		15435	16324
Ensembl ID		ENSG00000118363	ENSG00000197457
Uniprot IDs		Q15005	B7Z5G4 Q9NZ72
PDB IDs
Enriched GO Terms of Interacting Partners?		Alkanesulfonate Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation L-glutamate Uptake Involved In Synaptic Transmission Regulation Of Catalytic Activity Activation Of Phospholipase A2 Activity Cellular Response To Manganese Ion Positive Regulation Of Phospholipase A2 Activity Neuron Differentiation Age-dependent Response To Oxidative Stress Response To Cobalamin Response To UV-A Learning Or Memory Negative Regulation Of Rac Protein Signal Transduction Response To Hydroxyisoflavone Cognition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Somatic Motor Neuron Differentiation L-glutamate Import Response To Metal Ion Microtubule Depolymerization Positive Regulation Of Catenin Import Into Nucleus Transcription From Mitochondrial Promoter Regulation Of Phospholipase A2 Activity Generation Of Neurons Regulation Of Superoxide Anion Generation Neurotransmitter Uptake Mitochondrion Organization Neurofilament Cytoskeleton Organization Response To Oxidative Stress Neurogenesis Magnesium Ion Homeostasis Neuromuscular Process Controlling Posture Single-organism Behavior Amino Acid Import Response To Inorganic Substance Response To Manganese Ion Cellular Response To Estradiol Stimulus Protein Insertion Into Membrane Astrocyte Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Catenin Import Into Nucleus Regulation Of Rac GTPase Activity Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Sensory Organ Development L-glutamate Transport Behavior	Regulation Of Hormone Secretion Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Secretion Cellular Response To Oxygen Levels Positive Regulation Of Androgen Secretion Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Estrogen Receptor Binding Regulation Of Insulin Secretion Regulation Of Cellular Localization Regulation Of Peptide Hormone Secretion Protein Processing Regulation Of Signaling Response To Hypoxia Negative Regulation Of Receptor Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Dorsal Aorta Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Protein Secretion Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Signal Peptide Processing Mitotic Cell Cycle Arrest Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis CAMP-mediated Signaling Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Hormone Stimulus Aorta Development Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Regulation Of Protein Transport
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