SPCS2 and TEFM

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SPCS2	TEFM
Gene Name		signal peptidase complex subunit 2 homolog (S. cerevisiae)	transcription elongation factor, mitochondrial
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane	Mitochondrion Mitochondrial Matrix Ribonucleoprotein Complex Mitochondrial Nucleoid
	Molecular Function	Peptidase Activity	Protein Binding Crossover Junction Endodeoxyribonuclease Activity DNA Polymerase Processivity Factor Activity Poly(A) RNA Binding
	Biological Process	Translation Signal Peptide Processing Proteolysis SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Cellular Protein Metabolic Process Regulation Of Insulin Secretion	Oxidative Phosphorylation DNA Metabolic Process Mitochondrial DNA Replication Regulation Of Transcription, DNA-templated Transcription From Mitochondrial Promoter
Pathways		Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Translation Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ATP13A2 CLN8 EGFR STMN3 TEFM	2 interactors: PPP1CC SPCS2
Entrez ID		9789	79736
HPRD ID		15435	08005
Ensembl ID		ENSG00000118363
Uniprot IDs		Q15005	Q96QE5
PDB IDs
Enriched GO Terms of Interacting Partners?		Alkanesulfonate Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation L-glutamate Uptake Involved In Synaptic Transmission Regulation Of Catalytic Activity Activation Of Phospholipase A2 Activity Cellular Response To Manganese Ion Positive Regulation Of Phospholipase A2 Activity Neuron Differentiation Age-dependent Response To Oxidative Stress Response To Cobalamin Response To UV-A Learning Or Memory Negative Regulation Of Rac Protein Signal Transduction Response To Hydroxyisoflavone Cognition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Somatic Motor Neuron Differentiation L-glutamate Import Response To Metal Ion Microtubule Depolymerization Positive Regulation Of Catenin Import Into Nucleus Transcription From Mitochondrial Promoter Regulation Of Phospholipase A2 Activity Generation Of Neurons Regulation Of Superoxide Anion Generation Neurotransmitter Uptake Mitochondrion Organization Neurofilament Cytoskeleton Organization Response To Oxidative Stress Neurogenesis Magnesium Ion Homeostasis Neuromuscular Process Controlling Posture Single-organism Behavior Amino Acid Import Response To Inorganic Substance Response To Manganese Ion Cellular Response To Estradiol Stimulus Protein Insertion Into Membrane Astrocyte Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Catenin Import Into Nucleus Regulation Of Rac GTPase Activity Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Sensory Organ Development L-glutamate Transport Behavior	Signal Peptide Processing Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Glycogen Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Triglyceride Metabolic Process SRP-dependent Cotranslational Protein Targeting To Membrane Regulation Of Circadian Rhythm Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus
Tagcloud ?			c17orf42 coincident comprising dead dhx30 dsdna elongation foci helicase hereafter hhh incompetence makes mitochondria mitochondrial motifs owing pentatricopeptide polrmt processivity ptcd3 purification ribonuclease rnase spt6 ss strand templates transcripts
Tagcloud (Difference) ?			c17orf42 coincident comprising dead dhx30 dsdna elongation foci helicase hereafter hhh incompetence makes mitochondria mitochondrial motifs owing pentatricopeptide polrmt processivity ptcd3 purification ribonuclease rnase spt6 ss strand templates transcripts
Tagcloud (Intersection) ?