TUBB4A and CLN8

Number of citations of the paper that reports this interaction (PMID 23142642)
0

Data Source:
BioGRID (two hybrid)

		TUBB4A	CLN8
Gene Name		tubulin, beta 4A class IVa	ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Microtubule Cilium Internode Region Of Axon Neuronal Cell Body Myelin Sheath Extracellular Vesicular Exosome	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Folding Organelle Organization Microtubule-based Process Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Transmembrane Transport	Age-dependent Response To Oxidative Stress Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Regulation Of Cell Size Lipid Biosynthetic Process Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Apoptotic Process Cellular Protein Catabolic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Negative Regulation Of Transferase Activity L-glutamate Uptake Involved In Synaptic Transmission Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization
Pathways		Transport of connexons to the plasma membrane Hedgehog 'off' state Formation of tubulin folding intermediates by CCT/TriC Regulation of PLK1 Activity at G2/M Transition Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation Recruitment of mitotic centrosome proteins and complexes Orphan transporters Gap junction assembly Gap junction trafficking Factors involved in megakaryocyte development and platelet production Resolution of Sister Chromatid Cohesion Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes M Phase Intraflagellar transport Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Protein folding Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog Chaperonin-mediated protein folding Centrosome maturation
Drugs		Epothilone D Epothilone B
Diseases
GWAS			Gaucher disease severity ( 22388998)
Protein-Protein Interactions		5 interactors: BMPR2 CLN8 NR4A1 STAU1 YWHAG	29 interactors: ARL6IP5 BNIP3 BNIP3L C14orf1 CD9 CYB5B GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUFSP
Entrez ID		10382	2055
HPRD ID		04045	06383
Ensembl ID		ENSG00000104833	ENSG00000182372
Uniprot IDs		B4DJ43 P04350	Q9UBY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Size Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Lung Blood Pressure Negative Regulation Of Chondrocyte Proliferation L-glutamate Uptake Involved In Synaptic Transmission Positive Regulation Of Epithelial Cell Proliferation Retina Development In Camera-type Eye Negative Regulation Of Protein Metabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Vasoconstriction Age-dependent Response To Oxidative Stress Regulation Of Epithelial Cell Proliferation Somatic Motor Neuron Differentiation Negative Regulation Of Transferase Activity Positive Regulation Of Axon Extension Involved In Axon Guidance Lymphatic Endothelial Cell Differentiation L-glutamate Import Regulation Of Cellular Component Size Cell Differentiation Regulation Of Apoptotic Process Negative Regulation Of Proteolysis Intracellular MRNA Localization Camera-type Eye Development Negative Regulation Of Protein Processing Lymphangiogenesis Regulation Of Cell Death Generation Of Neurons Neurotransmitter Uptake Eye Development Regulation Of Protein Processing Lymph Vessel Morphogenesis Neurofilament Cytoskeleton Organization Endothelial Cell Chemotaxis Neurogenesis Neuromuscular Process Controlling Posture Tissue Development Regulation Of Axon Extension Involved In Axon Guidance Amino Acid Import Venous Blood Vessel Development System Development Intracellular Signal Transduction Cell Migration Involved In Sprouting Angiogenesis Blood Vessel Development Positive Regulation Of Viral Genome Replication	Mitochondrial Protein Catabolic Process Transport Membrane Organization Apoptotic Signaling Pathway Mitochondrion Organization Mitochondrial Outer Membrane Permeabilization Establishment Of Localization In Cell Negative Regulation Of Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Membrane Fusion Apoptotic Process Cellular Localization Programmed Cell Death Cell Death Death Mitochondrial Transport Organelle Organization Intracellular Transport Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Oligodendrocyte Development Substantia Nigra Development Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway Response To Stress Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Neural Nucleus Development Gliogenesis Mitochondrial Membrane Organization Protein Transport Dense Core Granule Maturation Apoptotic Mitochondrial Changes Positive Regulation Of Apoptotic Process Oligodendrocyte Differentiation Establishment Of Protein Localization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Response To Stress Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Serotonin Uptake Midbrain Development Glial Cell Development Cellular Response To Hypoxia Cell Communication Cellular Response To Decreased Oxygen Levels Negative Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway
Tagcloud ?			brainstem ceroid cln6 connectivity displayed epilepsy exclusively flurothyl generalized infantile kindled kindling latencies latency lipofuscinoses mnd nclf neuronal northern phenotypes plasticity postnatal posture reexposed repeated retesting seizure seizures shared
Tagcloud (Difference) ?			brainstem ceroid cln6 connectivity displayed epilepsy exclusively flurothyl generalized infantile kindled kindling latencies latency lipofuscinoses mnd nclf neuronal northern phenotypes plasticity postnatal posture reexposed repeated retesting seizure seizures shared
Tagcloud (Intersection) ?