TUBB4A

Gene Name		tubulin, beta 4A class IVa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Microtubule Cilium Internode Region Of Axon Neuronal Cell Body Myelin Sheath Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Folding Organelle Organization Microtubule-based Process Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Transmembrane Transport
Pathways		Transport of connexons to the plasma membrane Hedgehog 'off' state Formation of tubulin folding intermediates by CCT/TriC Regulation of PLK1 Activity at G2/M Transition Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation Recruitment of mitotic centrosome proteins and complexes Orphan transporters Gap junction assembly Gap junction trafficking Factors involved in megakaryocyte development and platelet production Resolution of Sister Chromatid Cohesion Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes M Phase Intraflagellar transport Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Protein folding Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog Chaperonin-mediated protein folding Centrosome maturation
Drugs		Epothilone D Epothilone B
Diseases
GWAS
Protein-protein Interactions		5 interactors: BMPR2 CLN8 NR4A1 STAU1 YWHAG
Entrez ID		10382
HPRD ID		04045
Ensembl ID		ENSG00000104833
Uniprot IDs		B4DJ43 P04350
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Size Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Lung Blood Pressure Negative Regulation Of Chondrocyte Proliferation L-glutamate Uptake Involved In Synaptic Transmission Positive Regulation Of Epithelial Cell Proliferation Retina Development In Camera-type Eye Negative Regulation Of Protein Metabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Vasoconstriction Age-dependent Response To Oxidative Stress Regulation Of Epithelial Cell Proliferation Somatic Motor Neuron Differentiation Negative Regulation Of Transferase Activity Positive Regulation Of Axon Extension Involved In Axon Guidance Lymphatic Endothelial Cell Differentiation L-glutamate Import Regulation Of Cellular Component Size Cell Differentiation Regulation Of Apoptotic Process Negative Regulation Of Proteolysis Intracellular MRNA Localization Camera-type Eye Development Negative Regulation Of Protein Processing Lymphangiogenesis Regulation Of Cell Death Generation Of Neurons Neurotransmitter Uptake Eye Development Regulation Of Protein Processing Lymph Vessel Morphogenesis Neurofilament Cytoskeleton Organization Endothelial Cell Chemotaxis Neurogenesis Neuromuscular Process Controlling Posture Tissue Development Regulation Of Axon Extension Involved In Axon Guidance Amino Acid Import Venous Blood Vessel Development System Development Intracellular Signal Transduction Cell Migration Involved In Sprouting Angiogenesis Blood Vessel Development Positive Regulation Of Viral Genome Replication
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