VRTN and RAB3A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VRTN	RAB3A
Description		vertebrae development associated	RAB3A, member RAS oncogene family
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Acrosomal Vesicle Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Synaptic Vesicle Membrane Transport Vesicle Axon Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Vesicle Cell Projection Terminal Bouton Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane Presynapse Postsynapse Extracellular Vesicle
	Molecular Function	DNA Binding Protein Binding Sequence-specific DNA Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein-macromolecule Adaptor Activity GTP-dependent Protein Binding Myosin V Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Plasma Membrane Repair Respiratory System Process Exocytosis Mitochondrion Organization Neuromuscular Synaptic Transmission Axonogenesis Post-embryonic Development Protein Transport Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Lung Development Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Lysosome Localization Synaptic Vesicle Recycling Constitutive Secretory Pathway Regulated Exocytosis Positive Regulation Of Exocytosis Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Transport Maintenance Of Presynaptic Active Zone Structure Sensory Perception Of Touch Response To Electrical Stimulus Establishment Of Localization In Cell Acrosomal Vesicle Exocytosis Evoked Neurotransmitter Secretion Synaptic Vesicle Clustering Regulation Of Presynaptic Dense Core Granule Exocytosis Positive Regulation Of Regulated Secretory Pathway Regulation Of Plasma Membrane Repair
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		FEV1 ( 30804560) Lung function (FVC) ( 30804560) Refractive error ( 32231278)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		10 interacting genes: C9orf72 CTBP2 EIF4A3 FAM90A1 POLR3C RAB2B RAB3A RAB3B RAB3C RAB3D	32 interacting genes: A2M ADRB2 AP1M2 APP CASK CHM CHML CHRM4 DMXL2 ECSIT EGFR GRSF1 KRTAP10-8 MAST1 MYO5A PSEN1 RAB3IL1 RAB3IP RABAC1 RABGGTB RABIF REP15 RIMS1 RIMS2 RNF32 RPH3A RPH3AL SGSM2 SNCA SYTL4 SYTL5 VRTN
Entrez ID		55237	5864
HPRD ID		16593	01535
Ensembl ID		ENSG00000133980	ENSG00000105649
Uniprot IDs		Q9H8Y1	A0A024R7I7 P20336
PDB IDs
Enriched GO Terms of Interacting Partners?		Myosin V Binding Regulation Of Exocytosis GTP-dependent Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Secretion By Cell Regulation Of Secretion GTPase Activity Synaptic Vesicle GTP Binding Exocytosis Positive Regulation Of Exocytosis Vesicle-mediated Transport Endosome Regulation Of Synaptic Vesicle Cycle Secretion By Cell Regulation Of Transport Hydrolase Activity Vesicle Nucleotide Binding Secretion Protein Transport Postsynapse Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Regulation Of Presynaptic Dense Core Granule Exocytosis Evoked Neurotransmitter Secretion Positive Regulation Of Secretion By Cell Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Positive Regulation Of Secretion Positive Regulation Of Transport Sensory Perception Of Touch Positive Regulation Of Type I Interferon Production Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Regulation Of Dense Core Granule Exocytosis Acrosomal Vesicle Antigen Processing And Presentation Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Secretory Granule Zymogen Granule Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Intracellular Protein Localization Clathrin-sculpted Glutamate Transport Vesicle Membrane Regulation Of Regulated Secretory Pathway Selenocysteine Insertion Sequence Binding Regulation Of Translation At Postsynapse Regulation Of Type I Interferon Production Synaptic Vesicle Membrane Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Acrosomal Vesicle Exocytosis	Small GTPase Binding Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Intracellular Transport Intracellular Protein Localization Rab-protein Geranylgeranyltransferase Complex Synaptic Vesicle Priming Regulation Of Exocytosis Protein Geranylgeranylation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Vesicle-mediated Transport Synapse Intracellular Protein Transport Protein Prenylation Secretion By Cell Neurexin Family Protein Binding Exocytosis Modulation Of Excitatory Postsynaptic Potential Cytoplasmic Vesicle Secretion Regulation Of Regulated Secretory Pathway Synaptic Vesicle Positive Regulation Of Vesicle Fusion Neuronal Dense Core Vesicle Signal Release Positive Regulation Of Exocytosis Astrocyte Activation Involved In Immune Response Rab Geranylgeranyltransferase Activity Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Neurotransmitter Transport Synaptic Vesicle Exocytosis Regulation Of Vesicle Fusion Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Neurotransmitter Secretion Regulation Of Nervous System Process Regulation Of Secretion By Cell Structural Constituent Of Presynaptic Active Zone Modulation Of Inhibitory Postsynaptic Potential Maintenance Of Presynaptic Active Zone Structure Synapse Organization Regulation Of Synaptic Vesicle Exocytosis Presynaptic Membrane Cellular Response To Amyloid-beta
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