EN1 and TLE1

Number of citations of the paper that reports this interaction (PMID 18611861)
13

Data Source:
BioGRID (affinity chromatography technology, pull down)

		EN1	TLE1
Gene Name		engrailed homeobox 1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Membrane	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription	RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Anatomical Structure Morphogenesis Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Midbrain Development Hindbrain Development Midbrain-hindbrain Boundary Development Embryonic Forelimb Morphogenesis Multicellular Organism Growth Response To Cocaine Pigmentation Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Signal Transduction Notch Signaling Pathway Multicellular Organismal Development Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Anoikis
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer truncations of AMER1 destabilize the destruction complex FBXW7 Mutants and NOTCH1 in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes NOTCH1 Intracellular Domain Regulates Transcription deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by WNT in cancer
Drugs
Diseases
GWAS		Multiple sclerosis ( 19010793)	Hippocampal atrophy ( 22745009) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)
Protein-Protein Interactions		3 interactors: JUN PAX6 TLE1	85 interactors: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TLX3 TSC22D1 UTY VENTX ZFP64
Entrez ID		2019	7088
HPRD ID		08835	02557
Ensembl ID		ENSG00000163064	ENSG00000196781
Uniprot IDs		Q05925	Q04724
PDB IDs			1GXR 2CE8 2CE9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Organ Morphogenesis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Pancreatic A Cell Development Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Cellular Response To Potassium Ion Starvation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Leading Edge Cell Differentiation Positive Regulation Of Glucagon Secretion Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Gene Expression Rhombomere Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Asymmetric Cell Division Regulation Of Transcription From RNA Polymerase II Promoter Involved In Spinal Cord Motor Neuron Fate Specification Positive Regulation Of Cell Fate Specification Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Ventral Spinal Cord Interneuron Specification Pancreatic A Cell Differentiation Somatic Motor Neuron Differentiation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Monocyte Differentiation Forebrain Anterior/posterior Pattern Specification Cerebral Cortex Regionalization Negative Regulation Of Phosphorylation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Forebrain Dorsal/ventral Pattern Formation Regulation Of Glucagon Secretion Transcription, DNA-templated Oligodendrocyte Cell Fate Specification Lacrimal Gland Development Iris Morphogenesis SMAD Protein Import Into Nucleus RNA Biosynthetic Process Anatomical Structure Morphogenesis Cornea Development In Camera-type Eye Rhombomere Development Positive Regulation By Host Of Viral Transcription Insulin Metabolic Process Gland Development Formation Of Anatomical Boundary Negative Regulation By Host Of Viral Transcription Response To Drug Protein Localization To Organelle	System Development Nervous System Development Developmental Process Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Cell Differentiation Heterocycle Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Tissue Morphogenesis Regulation Of Gene Expression Epithelium Development Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Organ Morphogenesis Tissue Development Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Organ Development Embryo Development Regulation Of Nitrogen Compound Metabolic Process Neurogenesis RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Generation Of Neurons Anatomical Structure Morphogenesis Negative Regulation Of Transcription, DNA-templated Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Proliferation Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Central Nervous System Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process
Tagcloud ?		aer alternatives assure axes brief brought clues complements congenital correct deciphering deformity digit ectoderm eventually fgfs limb limbs lmx1b malformation manners modules organized p63 quantity shh sterile wnt7a zpa	activates carcinogenesis colony contributed contributes deregulation dramatically dysregulation enhancer growing hcc hepatic hepatitis hepatocarcinogenesis hepatocellular immunodeficient indicates insights kappa largely micrornas mir mirna mirnas transducin tumorigenesis untranslated utr whereby
Tagcloud (Difference) ?		aer alternatives assure axes brief brought clues complements congenital correct deciphering deformity digit ectoderm eventually fgfs limb limbs lmx1b malformation manners modules organized p63 quantity shh sterile wnt7a zpa	activates carcinogenesis colony contributed contributes deregulation dramatically dysregulation enhancer growing hcc hepatic hepatitis hepatocarcinogenesis hepatocellular immunodeficient indicates insights kappa largely micrornas mir mirna mirnas transducin tumorigenesis untranslated utr whereby
Tagcloud (Intersection) ?