EN1 and PAX6

Number of citations of the paper that reports this interaction (PMID 11069920)
19

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		EN1	PAX6
Gene Name		engrailed homeobox 1	paired box 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Membrane	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding AT DNA Binding Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Acetyltransferase Binding Co-SMAD Binding R-SMAD Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Anatomical Structure Morphogenesis Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Midbrain Development Hindbrain Development Midbrain-hindbrain Boundary Development Embryonic Forelimb Morphogenesis Multicellular Organism Growth Response To Cocaine Pigmentation Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Mitotic Spindle Orientation Blood Vessel Development Eye Development Cell Fate Determination Neural Crest Cell Migration Neuron Migration Negative Regulation Of Protein Phosphorylation Positive Regulation Of Neuroblast Proliferation Lens Development In Camera-type Eye Type B Pancreatic Cell Differentiation Pancreatic A Cell Development Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Axon Guidance Central Nervous System Development Salivary Gland Morphogenesis Visual Perception Response To Wounding Regulation Of Asymmetric Cell Division Organ Morphogenesis Dorsal/ventral Axis Specification Positive Regulation Of Gene Expression Regulation Of Neuron Projection Development Protein Ubiquitination Cerebellum Development Rhombomere Morphogenesis Olfactory Bulb Development Oligodendrocyte Cell Fate Specification Cerebral Cortex Regionalization Forebrain Anterior/posterior Pattern Specification Forebrain Dorsal/ventral Pattern Formation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Spinal Cord Motor Neuron Fate Specification Regulation Of Transcription From RNA Polymerase II Promoter Involved In Ventral Spinal Cord Interneuron Specification Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Pituitary Gland Development Interkinetic Nuclear Migration Signal Transduction Involved In Regulation Of Gene Expression Keratinocyte Differentiation Positive Regulation Of Epithelial Cell Differentiation Lacrimal Gland Development Cellular Response To Insulin Stimulus Protein Localization To Organelle Cellular Response To Drug Eye Photoreceptor Cell Development Glucose Homeostasis Positive Regulation Of Cell Fate Specification Cellular Response To Fibroblast Growth Factor Stimulus Response To Ethanol Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Timing Of Cell Differentiation Embryonic Camera-type Eye Morphogenesis Neuron Fate Commitment Astrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Retina Development In Camera-type Eye Iris Morphogenesis Cornea Development In Camera-type Eye Positive Regulation Of Glucagon Secretion Cellular Response To Glucose Stimulus Cellular Response To Prostaglandin E Stimulus Insulin Metabolic Process Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Neuron Migration
Pathways			Peptide hormone metabolism Regulation of beta-cell development Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Regulation of gene expression in beta cells Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS		Multiple sclerosis ( 19010793)	Body mass index ( 22344219)
Protein-Protein Interactions		3 interactors: JUN PAX6 TLE1	30 interactors: CDX2 DIAPH1 DLG1 DYNLL1 EN1 EP300 HIPK2 HOMER3 HOXB1 INADL IPO13 LHX2 MAFG MITF NKIRAS2 PBX1 PKNOX1 PROX1 RAX RB1 RGS3 SHANK3 SIX3 SMARCA4 SOX10 SOX3 SUMO1 TBP TRIM11 VSX2
Entrez ID		2019	5080
HPRD ID		08835	06167
Ensembl ID		ENSG00000163064	ENSG00000007372
Uniprot IDs		Q05925	F1T0F8 P26367 Q66SS1
PDB IDs			2CUE 6PAX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Organ Morphogenesis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Pancreatic A Cell Development Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Cellular Response To Potassium Ion Starvation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Leading Edge Cell Differentiation Positive Regulation Of Glucagon Secretion Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Gene Expression Rhombomere Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Asymmetric Cell Division Regulation Of Transcription From RNA Polymerase II Promoter Involved In Spinal Cord Motor Neuron Fate Specification Positive Regulation Of Cell Fate Specification Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Ventral Spinal Cord Interneuron Specification Pancreatic A Cell Differentiation Somatic Motor Neuron Differentiation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Monocyte Differentiation Forebrain Anterior/posterior Pattern Specification Cerebral Cortex Regionalization Negative Regulation Of Phosphorylation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Forebrain Dorsal/ventral Pattern Formation Regulation Of Glucagon Secretion Transcription, DNA-templated Oligodendrocyte Cell Fate Specification Lacrimal Gland Development Iris Morphogenesis SMAD Protein Import Into Nucleus RNA Biosynthetic Process Anatomical Structure Morphogenesis Cornea Development In Camera-type Eye Rhombomere Development Positive Regulation By Host Of Viral Transcription Insulin Metabolic Process Gland Development Formation Of Anatomical Boundary Negative Regulation By Host Of Viral Transcription Response To Drug Protein Localization To Organelle	Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Nervous System Development Anatomical Structure Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Organ Development Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Camera-type Eye Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development RNA Metabolic Process System Development Eye Development Multicellular Organismal Development Regulation Of Transcription, DNA-templated Sensory Organ Development Regulation Of Nucleic Acid-templated Transcription Developmental Process Organ Morphogenesis Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Neurogenesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chordate Embryonic Development Cellular Nitrogen Compound Metabolic Process Generation Of Neurons Embryo Development Ending In Birth Or Egg Hatching Embryonic Morphogenesis Pattern Specification Process Tissue Development
Tagcloud ?		aer alternatives assure axes brief brought clues complements congenital correct deciphering deformity digit ectoderm eventually fgfs limb limbs lmx1b malformation manners modules organized p63 quantity shh sterile wnt7a zpa	11p13 armes compaction conservation controversy cosmids editing evolution fried fugu genitourinary genomics gilley idea implying intergenic isoforms london mammals noncoding pufferfish quite raises rcn1 rubripes synteny usage usual wt1
Tagcloud (Difference) ?		aer alternatives assure axes brief brought clues complements congenital correct deciphering deformity digit ectoderm eventually fgfs limb limbs lmx1b malformation manners modules organized p63 quantity shh sterile wnt7a zpa	11p13 armes compaction conservation controversy cosmids editing evolution fried fugu genitourinary genomics gilley idea implying intergenic isoforms london mammals noncoding pufferfish quite raises rcn1 rubripes synteny usage usual wt1
Tagcloud (Intersection) ?